BOC Sciences recently announced that it will provide high-quality GMP and non-GMP-grade pseudouridine and its derivatives to meet the needs of pharmaceutical manufacturing and biological research industries.
Shirley, United States - July 30, 2021 /MarketersMedia/ —
In view of the importance of pseudouridine in the research of RNA-mediated cellular processes and the development of RNA drugs, BOC Sciences, a chemical and pharmaceutical raw material supplier based in New York, recently announced that it will provide high-quality GMP and non-GMP-grade pseudouridine and its derivatives to meet the needs of pharmaceutical manufacturing and biological research industries.
Relying on the GMP synthesis platform and rich experience in the development and synthesis of biochemical materials, BOC Sciences can provide more than 20 high-quality pseudouridine and its derivatives, which can be used for RNA drug development or other biological researches. The company’s current annual output of pseudouridine exceeds 500 kg, making it the largest producer of pseudouridine in the world.
Pseudouridine, also abbreviated to the Greek letter psi-Ψ or letter Q), is the most abundant RNA modification in the cell. As an isomer of the nucleoside uridine, pseudouridine is connected by a carbon-carbon rather than a nitrogen-carbon glycosidic bond. And its C-C bond gives pseudouridine more rotational freedom and conformational flexibility. In pseudouridine, 5-ribouracil has an additional hydrogen bond donor at the N1 position, which is a ubiquitous but mysterious component in structural RNA (rRNA, small nuclear RNA (snRNA), etc.).
Studies have shown that yeast tRNA nucleotides contain 4% pseudouridine. In addition, there are 11 pseudouridines in E. coli. rRNA, 30 pseudouridines in yeast cytoplasmic rRNA, and about 100 pseudouridines in human rRNA. Moreover, pseudouridine is a single modification in mitochondrial 21S rRNA. All of the above indicate that the degree of pseudouridylation increases with the complexity of the organism.
The functions of pseudouridine in RNAs
The pseudouridine in snRNA has been shown to enhance the spliceosome RNA-pre-mRNA interaction to promote splicing regulation. The pseudouridine in rRNA and tRNA fine-tunes and stabilizes the structure of the region via the formation of additional hydrogen bonds between its additional imino groups and water, and helps maintain mRNA decoding, ribosome assembly, processing, and translation.
As RNA degrades, pseudouridine and other nucleosides are released in the cell to form free nucleosides. Unlike the common nucleosides (adenine (A), guanine (G), cytosine (C), and uracil (U)), pseudouracil cannot be recycled by cells, so as not to disturb the RNA inherent modification map.
For more information on pseudouridine products, please visit the website of BOC Sciences: https://www.bocsci.com/pseudouridine-and-its-derivatives.html.
About BOC Sciences
BOC Sciences has well-known experts in multiple disciplines such as drug discovery, chemistry, and life sciences, and is a reliable supplier that provides a comprehensive collection of chemicals with GMP grade, industrial grade, or any other professional level for scientists and researchers in academia and industry. In the past two decades, it has won the reputation and valuable trust of global customers in the supply of chemicals such as pseudouridine and its derivatives. In addition, it also provides drug R&D services covering all stages to support the pharmaceutical industry.
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