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Blog Exposure - Tonix Declares Publication of Research about Potential Smallpox-Preventing Vaccine Candidate TNX-801

LONDON, UK / ACCESSWIRE / January 23, 2018 / Active-Investors.com has just released a free research report on Tonix Pharmaceuticals Holding Corp. (NASDAQ: TNXP) ("Tonix"). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=TNXP as the Company's latest news hit the wire. On January 19, 2018, the Company, which is an organization developing innovative pharmaceutical and biological products to address major public health challenges and diseases with significant unmet needs, announced the publication of a research outlining the successful synthesis and characterization of a potential smallpox-preventing vaccine based on horsepox virus. Register today and get access to over 1000 Free Research Reports by joining our site below:

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Active-Investors.com is focused on giving you timely information and the inside line on companies that matter to you. This morning, Tonix Pharmaceuticals Holding most recent news is on our radar and our team decided to put out a fantastic report on the company that is now available for free below:

www.active-investors.com/registration-sg/?symbol=TNXP

About the Research Publication

Tonix conducted this research in collaboration with scientists from the University of Alberta, a leading Canadian research university. The peer-reviewed article, ‘Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments', was published in the PLOS ONE journal. This came after Tonix's announcement of the complete synthesis of the horsepox virus using synthetic biology technology in March 2017. As per the research and development agreement, Tonix wholly owns the synthesized horsepox virus stock and related sequences.

Relation between Horsepox and Smallpox

Horsepox, which is an equine disease caused by the horsepox virus, is believed to have become extinct through some natural process. In fact, no horsepox outbreaks have been reported since 1976, at which time the US Department of Agriculture got the viral sample used for the sequence published in 2006, which is the basis for TNX-801. English physician and scientist, Dr. Edward Jenner, speculated in 1798 that a vaccine derived from cowpox could protect humans against smallpox. Jenner believes that this vaccine that he isolated from what was known as cowpox in cows, began as a pox disease in horses. And thus, smallpox was eradicated as a result of Jenner's vaccine.

Tonix is Developing a Synthetic Version of Horsepox Virus as a Potential Vaccine for Smallpox

Tonix is creating a synthetic version of the horsepox virus from cell culture, titled TNX-801, as a potential vaccine for preventing smallpox infection in humans. TNX-801 is a live form of horsepox virus (HPXV) that has proven to have protective vaccine activity in mice. At present, TNX-801 is in its pre-Investigational New Drug (IND) application stage. Evolutionary evidence shows that the vaccines that eradicated smallpox in the US and Europe in the 19th century were closely related to horsepox.

Seth Lederman, M.D., President and Chief Executive Officer (CEO) at Tonix, shared that, currently, smallpox vaccines are used to safeguard first responders and military service members in the Army's Global Response Force who face increased risks of smallpox outbreak. However, due to their toxicity and harmful side effects, the vaccines are not used for immunizing the whole at-risk population. Instead, they are stockpiled in the US Strategic National Stockpile. Therefore, Tonix looks forward to developing an improved smallpox preventing vaccine that has a better safety profile and is more appropriate for broader usage.

An Initiative in Public Interest

Professor David Evans, Ph.D., FCAHS, Professor and Vice-Dean (Research), Faculty of Medicine and Dentistry at the University of Alberta, in Edmonton, Alberta, Canada, and principal investigator of the TNX-801 research project believes that this research will facilitate informed discussions about potential applications of synthetic biology for improving public health, encouraging new evaluation of horsepox-based vaccines, and developing the manufacturing process to rapidly produce next-generation vaccines and therapeutics.

José Esparza, M.D., Ph.D., former President of the Global Virus Network, former Senior Advisor on Global Health (Vaccines) to the Bill and Melinda Gates Foundation, and currently adjunct professor at the Institute of Human Virology at the University of Maryland School of Medicine, also had similar views. He has not been personally involved in the research but he believes that an improved smallpox vaccine would address the well-recognized risk of the intentional re-introduction of the smallpox virus. He feels that ignoring the risk of smallpox intentional re-introduction, or depending on current vaccines that have limitations, would not be in the best interest of the public.

Professor Evans and Research Associate, Ryan Noyce, Ph.D., at the University of Alberta, synthesized Horsepox with Dr. Lederman as co-investigator of the research and co-inventor of TNX-801.

Stock Performance Snapshot

January 22, 2018 - At Monday's closing bell, Tonix Pharmaceuticals Holding's stock advanced 6.04%, ending the trading session at $4.04.

Volume traded for the day: 144.88 thousand shares, which was above the 3-month average volume of 72.46 thousand shares.

Stock performance in the last month – up 16.43%; and year-to-date - up 17.10%

After yesterday's close, Tonix Pharmaceuticals Holding's market cap was at $30.42 million.

The stock is part of the Healthcare sector, categorized under the Drug Manufacturers - Major industry. This sector was up 0.9% at the end of the session.

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