sv3
As
filed with the Securities and Exchange Commission on August 4, 2005
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
GTx, Inc.
(Exact name of registrant as specified in its charter)
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Delaware
(State or other jurisdiction of
incorporation or organization)
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62-1715807
(I.R.S. Employer Identification No.) |
3 N. Dunlap Street, 3rd Floor
Van Vleet Building
Memphis, TN 38163
(901) 523-9700
(Address, including zip code, and telephone number, including area code, of registrants principal executive offices)
MITCHELL S. STEINER, M.D., F.A.C.S.
CHIEF EXECUTIVE OFFICER
GTx, Inc.
3 N. Dunlap Street, 3rd Floor
Van Vleet Building
Memphis, TN 38163
(901) 523-9700
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Suzanne Sawochka Hooper, Esq.
Cooley Godward LLP
Five Palo Alto Square
3000 El Camino Real
Palo Alto, CA 94306-2155
(650) 843-5000
Approximate date of proposed sale to the public:
From time to time after the effective date of this Registration Statement.
If the only securities being registered on this form are being offered pursuant to
dividend or interest reinvestment plans, please check the following box. o
If any of the securities being registered on this form are to be offered on a delayed or
continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities
offered only in connection with dividend or interest reinvestment plans, check the following box.
þ
If this form is filed to register additional securities for an offering pursuant to Rule
462(b) under the Securities Act, please check the following box and list the Securities Act
registration statement number of the earlier effective registration statement for the same
offering. o
If this form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities
Act, check the following box and list the Securities Act registration statement number of the
earlier effective registration statement for the same offering. o
If delivery of the Prospectus is expected to be made pursuant to Rule 434, please check the
following box. o
CALCULATION OF REGISTRATION FEE
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Proposed Maximum |
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Amount of |
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Title of Securities to be Registered(1) |
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Aggregate Offering Price(2) |
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Registration Fee(3) |
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Common Stock, par value $.001 per share |
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$100,000,000 |
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$11,770 |
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(1) |
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There are being registered hereunder such indeterminate number of shares of common stock as
shall have an aggregate initial offering price not to exceed $100,000,000. |
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The proposed maximum aggregate offering price per share will be determined from time to time
by the registrant in connection with the issuance by the registrant of the securities
registered hereunder. |
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Calculated pursuant to Rule 457(o) under the Securities Act. |
The registrant hereby amends this registration statement on such date or dates as may be
necessary to delay its effective date until the registrant shall file a further amendment that
specifically states that this registration statement shall thereafter become effective in
accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement
shall become effective on such date as the Securities and Exchange Commission, acting pursuant to
said Section 8(a), may determine.
Information contained herein is subject to completion or amendment. A registration statement
relating to these securities has been filed with the Securities and Exchange Commission. These
securities may not be sold nor may offers to buy be accepted prior to the time the registration
statement becomes effective. This prospectus shall not constitute an offer to sell or the
solicitation of an offer to buy nor shall there be any sale of these securities in any State in
which such offer, solicitation or sale would be unlawful prior to registration or qualification
under the securities laws of any such State.
SUBJECT
TO COMPLETION, DATED August 4, 2005
PROSPECTUS
GTx, INC.
$100,000,000
Common Stock
From time to time, we may sell common stock in one or more offerings for an aggregate
initial offering price of up to $100,000,000.
We will provide the specific terms of any offering in one or more supplements to this
prospectus. You should read this prospectus and any prospectus supplement, as well as any documents
incorporated by reference in this prospectus and any prospectus supplement, carefully before you
invest.
Our common stock is quoted on the Nasdaq National Market under the trading symbol GTXI. On
August 3, 2005, the last reported sale price of our common stock on the Nasdaq National Market was
$11.50 per share.
THIS PROSPECTUS MAY NOT BE USED TO OFFER OR SELL ANY SECURITIES UNLESS ACCOMPANIED BY A
PROSPECTUS SUPPLEMENT.
If any underwriters are involved in the sale of any securities with respect to which this
prospectus is being delivered, the names of such underwriters and any applicable commissions or
discounts will be set forth in a prospectus supplement. The net proceeds we expect to receive from
such sale will also be set forth in a prospectus supplement.
NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS
APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR
COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
INVESTING IN OUR SECURITIES INVOLVES A HIGH DEGREE OF RISK. SEE THE SECTION ENTITLED RISK
FACTORS ON PAGE 2 OF THIS PROSPECTUS.
The date of this prospectus is _______________, 2005
GTX, INC.
GTx, Inc. is a biopharmaceutical company dedicated to the discovery, development and
commercialization of therapeutics for serious mens health conditions. Our drug discovery and
development programs are focused on small molecules that selectively modulate the effects of
estrogens and androgens.
We have four clinical programs. We are developing Acapodene (toremifene citrate) in two
clinical programs in men: (1) a pivotal Phase III clinical trial for the prevention of prostate
cancer in high risk men and (2) a pivotal Phase III clinical trial for the treatment of serious
side effects of androgen deprivation therapy for advanced prostate cancer. In our third clinical
program, we and our partner, Ortho Biotech Products, L.P., a subsidiary of Johnson & Johnson, are
developing andarine, a selective androgen receptor modulator, or SARM, for cancer cachexia. We are
working with Ortho Biotech to progress andarine into a Phase II clinical trial. In our fourth
clinical program, we are developing our second SARM, ostarine, for andropause and other chronic
wasting conditions related to aging, including frailty and sarcopenia. We also have the exclusive
right to market Fareston (toremifene citrate 60 mg) tablets, which have been approved by the U.S.
Food and Drug Administration for the treatment of metastatic breast cancer, in the United States.
The active pharmaceutical ingredient in Fareston is the same as in Acapodene, but at a different
dose.
We were originally incorporated under the name Genotherapeutics, Inc. in Tennessee in
September 1997. We changed our name to GTx, Inc. in 2001, and we reincorporated in Delaware in
2003. Our principal executive office is located at 3 N. Dunlap Street, Van Vleet Building,
Memphis, Tennessee, and our telephone number is (901) 523-9700. Our website address is
www.gtxinc.com. The information contained in our website is not a part of this prospectus or any
prospectus supplement.
Service marks, trademarks and trade names referred to in this prospectus are the property of
their respective owners.
ABOUT THIS PROSPECTUS
This prospectus is part of a registration statement that we filed with the Securities and
Exchange Commission using a shelf registration process. Under this shelf registration process, we
may sell common stock in one or more offerings, up to a total dollar amount of $100,000,000. This
prospectus provides you with a general description of the securities we may offer. Each time we
sell common stock, we will provide a prospectus supplement that will contain more specific
information about the terms of that offering. We may also add, update or change in the prospectus
supplement any of the information contained in this prospectus. However, no prospectus supplement
will fundamentally change the terms that are set forth in this prospectus or offer a security that
is not registered and described in this prospectus at the time of its effectiveness. This
prospectus, together with applicable prospectus supplements, includes all material information
relating to this offering. If there is any inconsistency between the information in this prospectus
and the information in the accompanying prospectus supplement, you should rely on the information
in the prospectus supplement. Please carefully read both this prospectus and any prospectus
supplement together with the additional information described below under Where You Can Find More
Information.
You should rely only on the information we have provided or incorporated by reference in this
prospectus or any prospectus supplement. We have not authorized anyone to provide you with
different information. No dealer, salesperson or other person is authorized to give any
information or to represent anything not contained in this prospectus or any prospectus supplement.
You must not rely on any unauthorized information or representation. This prospectus is an offer to
sell only the securities offered hereby, but only under circumstances and in jurisdictions where it
is lawful to do so. You should assume that the information in this prospectus or any prospectus
supplement is accurate only as of the date on the front of the document and that any information we
have incorporated by reference is accurate only as of the date of the document incorporated by
reference, regardless of the time of delivery of this prospectus or any sale of a security.
Unless otherwise mentioned or unless the context requires otherwise, all references in this
prospectus to GTx, we, our or similar references mean GTx, Inc.
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RISK FACTORS
Investment in our securities involves a high degree of risk. You should consider carefully the
risk factors in any prospectus supplement and in our filings with the Securities and Exchange
Commission, as well as other information in this prospectus and any prospectus supplement and the
documents incorporated by reference herein or therein, before purchasing any of our securities.
Each of the risk factors could adversely affect our business, operating results and financial
condition, as well as adversely affect the value of an investment in our securities.
FORWARD-LOOKING INFORMATION
This prospectus, any prospectus supplement and the documents that we incorporate by reference
contain statements indicating expectations about future performance and other forward-looking
statements that involve risks and uncertainties. We usually use words such as may, will,
should, expect, plan, anticipate, believe, estimate, predict, future, intend,
potential or continue or the negative of these terms or similar expressions to identify
forward-looking statements. These statements appear throughout this prospectus, any prospectus
supplement and the documents that we incorporate by reference and are statements regarding our
current intent, belief or expectation, primarily with respect to our operations and related
industry developments. Examples of these statements include, but are not limited to, statements
regarding the following: our current and anticipated clinical trials; the progress of our research
and development programs; our corporate collaborations, including potential future licensing fees
and milestone and royalty payments; our research and development expenses; protection of our
intellectual property; sufficiency of our cash resources; and our operations and legal risks. You
should not place undue reliance on these forward-looking statements. Our actual results could
differ materially from those anticipated in these forward-looking statements for many reasons.
Important factors that could cause or contribute to such differences include, but are not limited
to, those discussed in any prospectus supplement or in the documents we incorporate by reference in
this prospectus, particularly in the section entitled Additional Factors That Might Affect Future
Results contained in our filings made with the Securities and Exchange Commission from time to
time. Any forward-looking statement speaks only as of the date on which it is made, and we
undertake no obligation to update any forward-looking statement to reflect events or circumstances
after the date on which the statement is made or to reflect the occurrence of unanticipated events.
New factors emerge from time to time, and it is not possible for us to predict which factors will
arise. In addition, we cannot assess the impact of each factor on our business or the extent to
which any factor, or combination of factors, may cause actual results to differ materially from
those contained in any forward-looking statements.
USE OF PROCEEDS
Except as described in any prospectus supplement, we intend to use the net proceeds from the
sale of our common stock for research and development and general corporate purposes. We may also
use a portion of the net proceeds to acquire or invest in businesses, products and technologies
that are complementary to our own. Pending these uses, the net proceeds will be invested in
investment-grade, interest-bearing securities.
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DESCRIPTION OF CAPITAL STOCK
Our authorized capital stock consists of 60,000,000 shares of common stock, $0.001 par value
per share, and 5,000,000 shares of preferred stock, $0.001 par value per share. As of July 25,
2005, there were 24,664,716 shares of our common stock outstanding and no shares of preferred stock
outstanding.
Common Stock
The holders of common stock are entitled to one vote for each share held of record on all
matters submitted to a vote of the stockholders and do not have cumulative voting rights. The
affirmative vote of the holders of a majority of the shares of common stock entitled to vote on a
matter is required to approve the matter (except when a different vote is required by law, Nasdaq
rules, our certificate if incorporation or our bylaws), and directors are elected by plurality
vote. Subject to preferences that may be applicable to any outstanding shares of preferred stock,
the holders of common stock are entitled to receive ratably such dividends as may be declared by
the board of directors out of legally available funds. Upon our liquidation, dissolution or winding
up, holders of our common stock are entitled to share ratably in all assets remaining after payment
of liabilities and the liquidation preferences of any outstanding shares of preferred stock.
Holders of common stock have no preemptive rights and no right to convert their common stock into
any other securities. There are no redemption or sinking fund provisions applicable to our common
stock. All outstanding shares of our common stock are, and all shares of common stock that may be
issued under this prospectus will be, fully paid and non-assessable.
The foregoing summary description of our common stock is based on the provisions of our
certificate of incorporation and bylaws and the applicable provisions of the Delaware General
Corporation Law. This information may not be complete in all respects and is qualified entirely by
reference to the provisions of our certificate of incorporation, bylaws and the Delaware General
Corporation Law. For information on how to obtain copies of our certificate of incorporation and
bylaws, see Where You Can Find More Information.
The rights of the holders of our common stock are subject to, and may be adversely affected
by, the rights of holders of shares of any preferred stock that we may designate and issue in the
future.
Preferred Stock
Pursuant to our certificate of incorporation, our board of directors has the authority,
without further action by the stockholders (unless such stockholder action is required by
applicable law or Nasdaq rules), to issue up to 5,000,000 shares of preferred stock in one or more
series, to establish from time to time the number of shares to be included in each such series, to
fix the rights, preferences and privileges of the shares of each wholly unissued series and any
qualifications, limitations or restrictions thereon, and to increase or decrease the number of
shares of any such series, but not below the number of shares of such series then outstanding. Our
board of directors may authorize the issuance of preferred stock with voting or conversion rights
that could adversely affect the voting power or other rights of the holders of the common stock.
The issuance of preferred stock, while providing flexibility in connection with possible
acquisitions and other corporate purposes, could, among other things, have the effect of delaying,
deferring or preventing a change in control of us and may adversely affect the market price of the
common stock and the voting and other rights of the holders of common stock. We have no present
plans to issue preferred stock.
Registration Rights
As of the date of this prospectus, holders of approximately 11,141,057 shares of our common
stock are entitled to rights with respect to the registration of those shares of common stock under
the Securities Act of 1933. If we propose to register any of our securities under the Securities
Act, either for our own account or for the account of others, the holders of these shares are
entitled to notice of the registration and are entitled to include, at our expense, their shares of
common stock in the registration and any related underwriting, provided, among other conditions,
that the underwriters may limit the number of shares to be included in the registration. In
addition, the holders of certain of these shares may require us, at our expense and subject to
certain limitations, to file a registration statement under the Securities Act with respect to
their shares of our common stock. These holders have waived these registration rights in connection
with the offerings that might be made under this registration statement.
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Anti-Takeover Effects of Provisions of Delaware Law and Our Charter Documents
Delaware Takeover Statute. We are subject to the provisions of Section 203 of the Delaware
General Corporation Law. In general, the statute prohibits a publicly-held Delaware corporation
such as us from engaging in a business combination with an interested stockholder for a period of
three years after the date of the transaction in which the person became an interested stockholder,
unless the business combination is approved in a prescribed manner. For purposes of Section 203, a
business combination includes a merger, asset or stock sale or other transaction resulting in a
financial benefit to the interested stockholder, and an interested stockholder is a person who,
together with affiliates and associates, owns, or within three years prior, did own, 15% or more of
our voting stock. Section 203 of the Delaware General Corporation Law will generally have an
anti-takeover effect for transactions not approved in advance by our board of directors, including
discouraging attempts that might result in a premium over the market price for the shares of common
stock held by our stockholders.
Charter Documents. Our certificate of incorporation and bylaws provide that our board of
directors be divided into three classes of directors, with each class serving a staggered
three-year term. The classification system of electing directors may tend to discourage a third
party from making a tender offer or otherwise attempting to obtain control of us and may maintain
the composition of our current board of directors, as the classification of the board of directors
generally increases the difficulty of replacing a majority of directors. In addition, our
certificate of incorporation and bylaws:
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provide that any action required or permitted to be taken by our stockholders must
be effected at a duly called annual or special meeting of stockholders and may not be
effected by any consent in writing; |
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establish advance notice requirements for nominations for election to our board of
directors or for proposing matters that can be acted upon at a stockholder meeting; |
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provide that the authorized number of directors may be changed only by resolution of
the board of directors; and |
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provide that special meetings of our stockholders may be called only by the chairman
of our board of directors, our chief executive officer or our board of directors
pursuant to a resolution adopted by a majority of the total number of authorized
directors. |
The Delaware corporate law statute provides generally that the affirmative vote of a majority
of the shares entitled to vote is required to amend a corporations bylaws, unless a corporations
certificate of incorporation requires a greater percentage or also confers the power upon the
corporations directors. Our bylaws may be amended or repealed by:
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the affirmative vote of a majority of our directors then in office; or |
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the affirmative vote of the holders of at least 66-2/3% of the voting power of all
then-outstanding shares of our capital stock entitled to vote generally in the election of
directors. |
The provisions described in the preceding paragraph that are included in our certificate of
incorporation may only be amended or repealed by the affirmative vote of a majority of our
directors and the affirmative vote of the holders of at least 66-2/3% of the voting power of all
then-outstanding shares of our capital stock entitled to vote generally in the election of
directors.
These and other provisions contained in our certificate of incorporation and bylaws could
delay or discourage some types of transactions involving an actual or potential change in our
control or change in our management, including transactions in which stockholders might otherwise
receive a premium for their shares over then current prices, and may limit the ability of
stockholders to remove current management or approve transactions that stockholders may deem to be
in their best interests and, therefore, could adversely affect the price of our common stock.
Transfer Agent and Registrar
The
transfer agent and registrar for our common stock is Computershare.
Its address is 150 Royall Street, Canton, MA 02021.
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PLAN OF DISTRIBUTION
We may sell the common stock through underwriters or dealers, through agents, or directly to
one or more purchasers. One or more prospectus supplements will describe the terms of the offering
of the common stock, including:
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the name or names of any agents or underwriters; |
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the purchase price of the common stock and the proceeds we will receive from the sale; |
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any over-allotment options under which underwriters may purchase additional shares
of common stock from us; |
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any agency fees or underwriting discounts and other items constituting agents or
underwriters compensation; |
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any discounts or concessions allowed or reallowed or paid to dealers; and |
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any securities exchange or market on which the common stock may be listed. |
Only underwriters named in the prospectus supplement are underwriters of the common stock
offered by the prospectus supplement.
If underwriters are used in the sale, they will acquire the common stock for their own account
and may resell the common stock from time to time in one or more transactions, including negotiated
transactions, at a fixed public offering price or at varying prices determined at the time of sale.
The obligations of the underwriters to purchase the common stock will be subject to the conditions
set forth in the applicable underwriting agreement. We may offer the common stock to the public
through underwriting syndicates represented by managing underwriters or by underwriters without a
syndicate. Subject to certain conditions, the underwriters will be obligated to purchase all the
common stock offered by the prospectus supplement if they are to purchase any of such offered
shares. Any public offering price and any discounts or concessions allowed or reallowed or paid to
dealers may change from time to time. We may use underwriters with whom we have a material
relationship. We will describe in the prospectus supplement naming the underwriter, the nature of
any such relationship.
We may sell the common stock directly or through agents we designate from time to time. We
will name any agent involved in the offering and sale of the common stock and we will describe any
commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement
states otherwise, our agent will act on a best-efforts basis for the period of its appointment.
We may authorize agents or underwriters to solicit offers by certain types of institutional
investors to purchase the common stock from us at the public offering price set forth in the
prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on
a specified date in the future. We will describe the conditions to these contracts and the
commissions we must pay for solicitation of these contracts in the prospectus supplement.
We may provide agents and underwriters with indemnification against certain civil liabilities,
including liabilities under the Securities Act, or contribution with respect to payments that the
agents or underwriters may make with respect to such liabilities. Agents and underwriters may
engage in transactions with, or perform services for, us in the ordinary course of business.
Any underwriter may engage in overallotment, stabilizing transactions, short covering
transactions and penalty bids in accordance with Regulation M under the Securities Exchange Act of
1934. Overallotment involves sales in excess of the offering size, which create a short position.
Stabilizing transactions permit bids to purchase the underlying shares of common stock so long as
the stabilizing bids do not exceed a specified maximum price. Short covering transactions involve
exercise by underwriters of an over-allotment option or purchases of the common
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stock in the open market after the distribution is completed to cover short positions. Penalty
bids permit the underwriters to reclaim a selling concession from a dealer when the shares of
common stock originally sold by the dealer are purchased in a short covering transaction. Those
activities may cause the price of the common stock to be higher than it would otherwise be. If
commenced, the underwriters may discontinue any of the activities at any time.
Our common stock is quoted on the Nasdaq National Market. One or more underwriters may make a
market in our common stock, but the underwriters will not be obligated to do so and may discontinue
market making at any time without notice. We cannot give any assurance as to liquidity of the
trading market for our common stock.
Any underwriters who are qualified market makers on the Nasdaq National Market may engage in
passive market making transactions in the securities on the Nasdaq National Market in accordance
with Rule 103 of Regulation M under the Securities Exchange
Act of 1934, during the five business days
prior to the pricing of the offering, before the commencement of offers or sales of the securities.
Passive market makers must comply with applicable volume and price limitations and must be
identified as passive market makers. In general, a passive market maker must display its bid at a
price not in excess of the highest independent bid for such security; if all independent bids are
lowered below the passive market makers bid, however, the passive market makers bid must then be
lowered when certain purchase limits are exceeded.
In compliance with guidelines of the National Association of Securities Dealers, or NASD, the
maximum consideration or discount to be received by any NASD member or independent broker dealer
may not exceed 8% of the aggregate amount of the securities offered pursuant to this prospectus and
any applicable prospectus supplement.
LEGAL MATTERS
The validity of the securities being offered hereby will be passed upon by Cooley Godward LLP,
Palo Alto, California.
EXPERTS
Ernst & Young LLP, independent registered public accounting firm, has audited our financial
statements included in our Annual Report on Form 10-K for the year ended December 31, 2004, as set
forth in their report, which is incorporated by reference in this prospectus and elsewhere in the
registration statement. Our financial statements are incorporated by reference in reliance on
Ernst & Young LLPs report, given on their authority as experts in accounting and auditing.
WHERE YOU CAN FIND MORE INFORMATION
We are a reporting company and file annual, quarterly and current reports, proxy statements
and other information with the Securities and Exchange Commission. We have filed with the
Securities and Exchange Commission a registration statement on Form S-3 under the Securities Act
with respect to the common stock we are offering under this prospectus. This prospectus does not
contain all of the information set forth in the registration statement and the exhibits to the
registration statement. For further information with respect to us and the common stock we are
offering under this prospectus, we refer you to the registration statement and the exhibits filed
as a part of the registration statement. You may read and copy the registration statement, as well
as our reports, proxy statements and other information, at the Securities and Exchange Commissions
public reference room at 100 F Street, N.E., Room 1580, Washington, D.C. 20549. You can request
copies of these documents by writing to the Securities and Exchange Commission and paying a fee for
the copying cost. Please call the Securities and Exchange Commission at 1-800-SEC-0330 for more
information about the operation of the public reference room. Our Securities and Exchange
Commission filings are also available at the Securities and Exchange Commissions website at
http://www.sec.gov.
The Securities and Exchange Commission allows us to incorporate by reference information
that we file with it, which means that we can disclose important information to you by referring
you to those documents. The information incorporated by reference is an important part of this
prospectus. Information in this prospectus supersedes information incorporated by reference that we
filed with the Securities and Exchange Commission prior to the date of this prospectus, while
information that we file later with the Securities and Exchange Commission will
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automatically update and supersede this information. We incorporate by reference into this
registration statement and prospectus the documents listed below and any future filings we will
make with the Securities and Exchange Commission under Sections 13(a), 13(c), 14 or 15(d) of the
Securities Exchange Act of 1934, as amended, after the date of the initial registration statement
but prior to effectiveness of the registration statement and after the date of this prospectus but
prior to the termination of the offering of the securities covered by this prospectus, except in
each case for information contained in any such filing where we indicate that such information is
being furnished and is not to be considered filed under the Securities Exchange Act of 1934, as
amended.
The following documents filed with the Securities and Exchange Commission are incorporated by
reference in this prospectus:
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our Annual Report on Form 10-K, as amended, for the year ended December 31, 2004, filed with the
Securities and Exchange Commission on March 24, 2005; |
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our Quarterly Report on Form 10-Q, as amended, for the quarter ended March 31, 2005, filed with
the Securities and Exchange Commission on April 29, 2005; |
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our Current Report on Form 8-K filed with the Securities and Exchange Commission on
February 1, 2005; |
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our Current Report on Form 8-K filed with the Securities and Exchange Commission on
February 2, 2005; |
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our Current Report on Form 8-K/A filed with the Securities and Exchange Commission
on March 7, 2005; |
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our Current Report on Form 8-K filed with the Securities and Exchange Commission on
June 2, 2005; |
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our Quarterly Report on Form 10-Q for the quarter ended June 30, 2005, filed with
the Securities and Exchange Commission on July 27, 2005; and |
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the description of our common stock contained in our registration statement on Form
8-A filed with the Securities and Exchange Commission on January 13, 2004, including
all amendments and reports filed for the purpose of updating such information. |
We will furnish without charge to you, upon written or oral request, a copy of any or all of
the documents incorporated by reference, including exhibits to these documents. You should direct
any requests for documents to GTx, Inc., Attention: Corporate Secretary, 3 N. Dunlap Street, Van
Vleet Building, Memphis, TN 38163. Our phone number is (901) 523-9700.
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PART II
INFORMATION NOT REQUIRED IN THE PROSPECTUS
Item 14. Other Expenses of Issuance and Distribution
The following table sets forth the estimated costs and expenses, other than the underwriting
discounts and commissions, payable by the registrant in connection with the offering of the
securities being registered. All the amounts shown are estimates, except for the registration fee.
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Securities and Exchange Commission registration fee |
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11,770 |
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Accounting fees and expenses |
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100,000 |
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Legal fees and expenses |
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150,000 |
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Printing, transfer agent and miscellaneous expenses |
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75,000 |
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Total |
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336,770 |
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Item 15. Indemnification of Officers and Directors
Our certificate of incorporation contains provisions permitted under Delaware law relating to
the liability of directors. These provisions eliminate a directors personal liability for
monetary damages resulting from a breach of fiduciary duty, except in circumstances involving
wrongful acts, such as:
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any breach of the directors duty of loyalty to us or our stockholders; |
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any act or omission not in good faith or that involves intentional misconduct or a
knowing violation of the law; |
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any act related to unlawful stock repurchases, redemptions or other distribution or
payments of dividends; or |
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any transaction from which the director derived an improper personal benefit. |
These provisions do not limit or eliminate our rights or any stockholders rights to seek
non-monetary relief, such as an injunction or rescission, in the event of a breach of directors
fiduciary duty. These provisions will not alter a directors liability under federal securities
laws.
As permitted by Section 145 of the Delaware General Corporation Law, our bylaws require us to
indemnify our directors and executive officers to the fullest extent not prohibited by the Delaware
law. We may expand the extent of such indemnification by individual contracts with our directors
and executive officers. Further, we may decline to indemnify any director or executive officer in
connection with any proceeding initiated by such person or any proceeding by such person against us
or our directors, officers, employees or other agents, unless such indemnification is expressly
required to be made by law or the proceeding was authorized by our board of directors.
We have entered into indemnity agreements with each of our current directors and our executive
officers to give such directors and officers additional contractual assurances regarding the scope
of the indemnification set forth in our certificate of incorporation and bylaws and to provide
additional procedural protections. At present, there is no pending litigation or proceeding
involving any of our directors, officers or employees for which indemnification is sought, nor are
we aware of any threatened litigation that may result in claims for indemnification.
We have the power to indemnify our other officers, employees and other agents, as permitted by
Delaware law, but we are not required to do so.
We have a directors and officers insurance and registrant reimbursement policy. The policy
insures directors and officers against unindemnified losses arising from certain wrongful acts in
their capacities as directors and officers and reimburses the registrant for those losses for which
the registrant has lawfully indemnified the directors and officers. The policy contains various
exclusions, none of which apply to this offering.
II-1
The underwriting agreement that we might enter into (Exhibit 1.1) will provide for
indemnification by any underwriters of GTx, our directors, our officers who sign the registration
statement and our controlling persons for some liabilities, including liabilities arising under the
Securities Act of 1933.
Item 16. Exhibits and Financial Statement Schedules
(a) Exhibits
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Exhibit |
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Number |
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Description of Document |
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1.1
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Form of Underwriting Agreement.(1) |
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4.1
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Amended and Restated Certificate of Incorporation of the Company. |
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4.2
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Amended and Restated Bylaws of the Company.(2) |
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4.3
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Specimen Common Stock Certificate.(2) |
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5.1
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Opinion of Cooley Godward LLP. |
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23.1
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Consent of Ernst & Young LLP, independent registered public accounting firm. |
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23.2
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Consent of Cooley Godward LLP (included in Exhibit 5.1). |
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24.1
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Power of Attorney (included in the signature page). |
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(1) |
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To be filed by amendment or as an exhibit to a current report of the registrant on Form 8-K
and incorporated herein by reference. |
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(2) |
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Filed as an exhibit to the registrants registration statement on Form S-1 or amendments
thereto (File No. 333-109700), originally filed with the Securities and Exchange Commission on
October 15, 2003, as amended, and incorporated herein by reference. |
Item 17. Undertakings
The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post-effective
amendment to this registration statement:
(i) to include any prospectus required by section 10(a)(3) of the Securities Act of 1933;
(ii) to reflect in the prospectus any facts or events arising after the effective date of the
registration statement (or the most recent post-effective amendment thereof) which, individually or
in the aggregate, represent a fundamental change in the information set forth in the registration
statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and
any deviation from the low or high end of the estimated maximum offering range may be reflected in
the form of prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b)
if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in
the maximum aggregate offering price set forth in the Calculation of Registration Fee table in
the effective registration statement; and
II-2
(iii) to include any material information with respect to the plan of distribution not
previously disclosed in the registration statement or any material change to such information in
the registration statement.
provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if the information required to
be included in a post-effective amendment by those paragraphs is contained in periodic reports
filed with or furnished to the Securities and Exchange Commission by the registrant pursuant to
section 13 or 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in
the registration statement.
(2) That, for the purpose of determining any liability under the Securities Act of 1933, each
such post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of the securities at that time shall be deemed to be
the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities
being registered which remain unsold at the termination of this offering.
(4) That, for purposes of determining any liability under the Securities Act of 1933, each
filing of the registrants annual report pursuant to section 13(a) or section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plans
annual report pursuant to section 15(d) of the Securities Exchange Act of 1934) that is
incorporated by reference in the registration statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial bona fide offering thereof.
(5) That: (i) for purposes of determining any liability under the Securities Act of 1933, the
information omitted from the form of prospectus filed as part of this registration statement in
reliance upon Rule 430A and contained in the form of prospectus filed by the registrant pursuant to
Rule 424(b)(1) or (4) or 497(h) under the Securities Act of 1933 shall be deemed to be part of the
registration statement as of the time it was declared effective; and (ii) for the purpose of
determining any liability under the Securities Act of 1933, each post-effective amendment that
contains a form of prospectus shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
permitted to directors, officers and controlling persons of the registrant pursuant to the
foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy as expressed in
the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant in the successful
defense of any action, suit or proceeding) is asserted by a director, officer or controlling person
in connection with the securities being registered, the registrant will, unless in the opinion of
its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed
in the Securities Act of 1933 and will be governed by the final adjudication of such issue.
II-3
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and
has duly caused this registration statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Memphis, State of
Tennessee, on August 4, 2005.
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GTx, Inc. |
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By:
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/s/ Mitchell S. Steiner |
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Mitchell S. Steiner, M.D., F.A.C.S. |
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Chief Executive Officer |
POWER OF ATTORNEY
Know All Persons By These Presents, that each person whose signature appears below
constitutes and appoints Mitchell S. Steiner, Marc S. Hanover, Henry P. Doggrell and Mark E.
Mosteller, and each of them, as true and lawful attorneys-in-fact and agents, with full powers of
substitution and resubstitution, for them and in their name, place and stead, in any and all
capacities, to sign any and all amendments (including pre-effective and post-effective amendments)
to this registration statement and any additional registration statements filed pursuant to Rule
462, and to file the same, with all exhibits thereto, and other documents in connection therewith,
with the Securities and Exchange Commission (the SEC), and generally to do all such things in
their names and behalf in their capacities as officers and directors to enable GTx to comply with
the provisions of the Securities Act of 1933 and all requirements of the SEC, granting unto said
attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he or she might or could do in person, ratifying and confirming all that
said attorneys-in-fact and agents, or any of them, or their or his or her substitutes or
substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has
been signed below by the following persons in the capacities and on the dates indicated.
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Signatures |
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/s/ Mitchell S. Steiner
Mitchell S. Steiner
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Chief Executive Officer,
Vice-Chairman and Director
(Principal Executive Officer)
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August 4, 2005 |
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/s/ Mark E. Mosteller
Mark E. Mosteller
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Chief Financial Officer (Principal
Financial and Accounting Officer)
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August 4, 2005 |
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/s/ J.R. Hyde, III
J.R. Hyde, III
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Chairman of the Board of Directors
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August 4, 2005 |
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/s/ Marc S. Hanover
Marc S. Hanover
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Chief Operating Officer and Director
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August 4, 2005 |
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/s/ Andrew M. Clarkson
Andrew M. Clarkson
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Director
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August 4, 2005 |
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/s/ J. Kenneth Glass
J. Kenneth Glass
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Director
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August 4, 2005 |
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/s/ Robert Karr
Robert Karr
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Director
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August 4, 2005 |
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/s/ Rosemary Mazanet
Rosemary Mazanet, M.D., Ph.D.
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Director
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August 4, 2005 |
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/s/ John H. Pontius
John H. Pontius
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Director
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August 4, 2005 |
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/s/ Timothy R. G. Sear
Timothy R. G. Sear
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Director
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August 4, 2005 |
II-4
INDEX TO EXHIBITS
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Exhibit |
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Number |
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Description of Document |
1.1
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Form of Underwriting Agreement.(1) |
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4.1
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Amended and Restated Certificate of Incorporation of the Company. |
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4.2
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Amended and Restated Bylaws of the Company.(2) |
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4.3
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Specimen Common Stock Certificate.(2) |
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5.1
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Opinion of Cooley Godward LLP. |
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23.1
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Consent of Ernst & Young LLP, independent registered public accounting firm. |
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23.2
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Consent of Cooley Godward LLP (included in Exhibit 5.1). |
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24.1
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Power of Attorney (included in the signature page). |
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(1) |
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To be filed by amendment or as an exhibit to a current report of the registrant on Form 8-K
and incorporated herein by reference. |
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(2) |
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Filed as an exhibit to the registrants registration statement on Form S-1 or amendments
thereto (File No. 333-109700), originally filed with the Securities and Exchange Commission on
October 15, 2003, as amended, and incorporated herein by reference. |