SECURITIES & EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                  SCHEDULE 13G
                  Under the Securities and Exchange Act of 1934

                              (Amendment No. ___)*

                           EPIX Pharmaceuticals, Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                    26881Q101
                                 (CUSIP Number)

                                February 25, 2005
             (Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule 13G is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





                              (Page 1 of 12 Pages)
----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).






CUSIP No.26881Q101                 13G                    Page 2 of 12 Pages

----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)

                   Hunter Global Associates L.L.C.

-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                331,950
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                331,950
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                331,950
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                1.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                OO
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.26881Q101                 13G                    Page 3 of 12 Pages

----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)

                        Hunter Global Investors L.P.

-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION 
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,202,685
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,202,685
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,202,685
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.2%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON ** 
                                                IA
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.26881Q101                 13G                    Page 4 of 12 Pages

----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)

                        Duke Buchan III
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,202,685
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,202,685
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,202,685
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.2%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                IN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.26881Q101                 13G                    Page 5 of 12 Pages

----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)

                        Hunter Global Investors Fund I L.P.

-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                318,720
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                318,720
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                318,720
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                1.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON ** 
                                                PN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.26881Q101                 13G                   Page 6 of 12 Pages

----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)

                        Hunter Global Investors Fund II L.P.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION 
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                13,230
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                13,230
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                13,230
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                0.1%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON ** 
                                                PN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.26881Q101                 13G                   Page 7 of 12 Pages


Item 1(a).        Name of Issuer:

                  The name of the issuer is EPIX Pharmaceuticals, Inc.
(the "Issuer").

Item 1(b).        Address of Issuer's Principal Executive Offices:

                  The Issuer's principal executive offices are located at
161 First Street, Cambridge, MA 02142

Item 2(a).        Name of Person Filing:

                  This statement is filed by:
                           (i)   Hunter Global Associates L.L.C., a Delaware
                                 limited liability company ("Associates") (OO)
                                 that is the general partner of Hunter Global
                                 Investors Fund I L.P. ("Fund I") and Hunter
                                 Global Investors Fund II L.P. ("Fund II"), with
                                 respect to the shares of Common Stock (defined
                                 in Item 2(d) below) beneficially owned by Fund
                                 I and Fund II, collectively.
                           (ii)  Hunter Global Investors L.P., a Delaware
                                 limited partnership ("Investors") (IA) that is
                                 the investment manager of Fund I, Fund II,
                                 Hunter Global Investors Offshore Fund Ltd., a
                                 Cayman Islands exempted company ("Off I") and
                                 Hunter Global Investors Offshore Fund II Ltd.,
                                 a Cayman Islands exempted company ("Off II"),
                                 with respect to the shares of Common Stock
                                 beneficially owned by Fund I, Fund II, Off I
                                 and Off II, collectively.
                           (iii) Duke Buchan III ("Mr. Buchan") (IN), who is the
                                 managing member of Associates and who controls
                                 Investors through its general partner, with
                                 respect to the shares of Common Stock
                                 beneficially owned by Fund I, Fund II, Off I
                                 and Off II, collectively.
                           (iv)  Fund I, a Delaware limited partnership (PN),
                                 with respect to the shares of Common Stock
                                 beneficially owned by it.
                           (v)   Fund II, a Delaware limited partnership (PN),
                                 with respect to the shares of Common Stock
                                 beneficially owned by it.

                           The foregoing persons are hereinafter collectively
                  referred to as the "Reporting Persons". Any disclosures herein
                  with respect to persons other than the Reporting Persons are
                  made on information and belief after making inquiry to the
                  appropriate person.

Item 2(b).        Address of Principal Business Office or, if none, Residence

         The address of the business office of each of the Reporting Persons is
485 Madison Avenue, 22nd Floor, New York, New York 10022.






CUSIP No.26881Q101                 13G                   Page 8 of 12 Pages

Item 2(c).        Citizenship

      Fund I, Fund II and Investors are each limited partnerships organized
under the laws of the State of Delaware. Associates is a limited liability
company organized under the laws of the State of Delaware. Mr. Buchan is a
United States citizen.

Item 2(d).        Title of Class of Securities

      Common Stock (the "Common Stock")

Item 2(e).        CUSIP Number

      26881Q101

Item 3.  If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b) or
(c), check whether the person filing is a:  NOT APPLICABLE

          (a) [ ] Broker or dealer registered under Section 15 of the Act,
          (b) [ ] Bank as defined in Section 3(a)(6) of the Act,
          (c) [ ] Insurance Company as defined in Section 3(a)(19) of the Act,
          (d) [ ] Investment Company registered under Section 8 of the
                  Investment Company Act of 1940,
          (e) [ ] Investment Adviser in accordance with Rule 13d-1(b)(1)(ii)(E),
          (f) [ ] Employee Benefit Plan or Endowment Fund in accordance with
                  13d-1 (b)(1)(ii)(F), (g) [ ] Parent Holding Company or control
                  person in accordance with Rule 13d-1 (b)(1)(ii)(G),
          (h) [ ] Savings Association as defined in Section 3(b) of the
                  Federal Deposit Insurance Act,
          (i) [ ] Church Plan that is excluded from the definition of an
                  investment company under Section 3(c)(14) of the Investment
                  Company Act of 1940,
          (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

Item 4.   Ownership.

      The percentages used in this Item 4 are calculated based upon 23,089,499
shares of Common Stock issued and outstanding as reported on Form 10-Q filed by
the Issuer with the Commission on November 2, 2004.

         A.   Hunter Global Associates L.L.C., as general partner of Hunter
              Global Investors Fund I L.P. and Hunter Global Investors Fund II
              L.P.
                (a) Amount beneficially owned: 331,950
                (b) Percent of class: 1.4%






CUSIP No.26881Q101                 13G                   Page 9 of 12 Pages

                (c) (i) Sole power to vote or direct the vote: -0- 
                   (ii) Shared power to vote or direct the vote: 331,950
                  (iii) Sole power to dispose or direct the disposition: -0-
                   (iv) Shared power to dispose or direct the disposition:
                        331,950

         B.   Hunter Global Investors L.P., as investment manager of Hunter
              Global Investors Fund I L.P., Hunter Global Investors Fund II
              L.P., Hunter Global Investors Offshore Fund Ltd. and Hunter Global
              Investors Offshore Fund II Ltd.

                (a) Amount beneficially owned: 1,202,685
                (b) Percent of class: 5.2%
                (c) (i) Sole power to vote or direct the vote: -0-
                   (ii) Shared power to vote or direct the vote: 1,202,685
                  (iii) Sole power to dispose or direct the disposition: -0-
                   (iv) Shared power to dispose or direct the disposition:
                        1,202,685

         C.   Duke Buchan III, as senior managing member of Hunter Global
              Associates L.L.C., and as the sole member of the general partner
              of Hunter Global Investors L.P.
                (a) Amount beneficially owned: 1,202,685 
                (b) Percent of class: 5.2%
                (c) (i) Sole power to vote or direct the vote: -0-
                   (ii) Shared power to vote or direct the vote: 1,202,685
                  (iii) Sole power to dispose or direct the disposition: -0-
                   (iv) Shared power to dispose or direct the disposition: 
                        1,202,685

         D.   Hunter Global Investors Fund I L.P.
                (a) Amount beneficially owned: 318,720 
                (b) Percent of class: 1.4% 
                (c) (i) Sole power to vote or direct the vote: -0-
                   (ii) Shared power to vote or direct the vote: 318,720
                  (iii) Sole power to dispose or direct the disposition: -0-
                   (iv) Shared power to dispose or direct the disposition: 
                        318,720

         E.   Hunter Global Investors Fund II L.P.
                (a) Amount beneficially owned: 13,230 
                (b) Percent of class: 0.1% 
                (c) (i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 13,230
              (iii) Sole power to dispose or direct the disposition: -0-
               (iv) Shared power to dispose or direct the disposition: 13,230






CUSIP No.26881Q101                 13G                   Page 10 of 12 Pages

Item 5.  Ownership of Five Percent or Less of a Class

            Not applicable.

Item 6.  Ownership of More than Five Percent on Behalf of Another Person

            Mr. Buchan, the senior managing member of Associates and the sole
member of the general partner of Investors, has the power to direct the affairs
of Associates, Investors, Fund I, Fund II, Off I and Off II, including
decisions with respect to the disposition of proceeds from the sale of the
Common Stock.

Item 7.  Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on By the Parent Holding Company

            Not applicable.

Item 8.  Identification and Classification of Members of the Group

            The identity of each member of the group is set forth above under
Item 2(a) and Item 4.

Item 9.  Notice of Dissolution of Group

            Not applicable.






CUSIP No.26881Q101                 13G                   Page 11 of 12 Pages

Item 10. Certification.

     Each of the Reporting Persons hereby makes the following certification:

            By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.

                                   SIGNATURES

     After reasonable inquiry and to the best of our knowledge and belief,
the undersigned certify that the information set forth in this statement is
true, complete and correct.

DATED:  March 3, 2005          By:     /s/ DUKE BUCHAN III                 
                                       ------------------------------------
                                       Duke Buchan III, individually and (a) as
                                       Senior Managing Member of Hunter Global
                                       Associates L.L.C., for itself and as the
                                       general partner of (i) Hunter Global
                                       Investors Fund I L.P. and (ii) Hunter
                                       Global Investors Fund II L.P. and (b) as
                                       Managing Member of Hunter Global Capital
                                       Management L.L.C., as the general partner
                                       of Hunter Global Investors L.P.






CUSIP No.26881Q101                  13G               Page 12 of 12 Pages

                                    EXHIBIT 1

                           JOINT ACQUISITION STATEMENT
                            PURSUANT TO RULE 13d-1(k)


     The undersigned acknowledge and agree that the foregoing statement on
Schedule 13G, is filed on behalf of each of the undersigned and that all
subsequent amendments to this statement on Schedule 13G, shall be filed on
behalf of each of the undersigned without the necessity of filing additional
joint acquisition statements. The undersigned acknowledge that each shall be
responsible for the timely filing of such amendments, and for the completeness
and accuracy of the information concerning him or it contained therein, but
shall not be responsible for the completeness and accuracy of the information
concerning the others, except to the extent that he or it knows or has reason to
believe that such information is inaccurate.


DATED:  March 3, 2005          By:     /s/ DUKE BUCHAN III                 
                                       ------------------------------------
                                       Duke Buchan III, individually and (a) as
                                       Senior Managing Member of Hunter Global
                                       Associates L.L.C., for itself and as the
                                       general partner of (i) Hunter Global
                                       Investors Fund I L.P. and (ii) Hunter
                                       Global Investors Fund II L.P. and (b) as
                                       Managing Member of Hunter Global Capital
                                       Management L.L.C., as the general partner
                                       of Hunter Global Investors L.P.