UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 2)


                                CERUS CORPORATION
--------------------------------------------------------------------------------
                                (NAME OF ISSUER)



                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (TITLE OF CLASS OF SECURITIES)



                                    157085101
--------------------------------------------------------------------------------
                                 (CUSIP NUMBER)



                                DECEMBER 31, 2005
--------------------------------------------------------------------------------
             (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)




Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|      Rule 13d-1(b)
|X|      Rule 13d-1(c)
|_|      Rule 13d-1(d)





CUSIP No. 157085101                    13G                    PAGE 2 of 10 PAGES

--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

          ING Groep N.V.
--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                        (a) |_|
          Not Applicable                                                (b) |_|
--------------------------------------------------------------------------------
   3      SEC USE ONLY


--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION

          The Netherlands
--------------------------------------------------------------------------------
                    5  SOLE VOTING POWER

                       1,086,640
                    ------------------------------------------------------------
   NUMBER OF        6  SHARED VOTING POWER
    SHARES
 BENEFICIALLY          0
 OWNED BY EACH      ------------------------------------------------------------
   REPORTING        7  SOLE DISPOSITIVE POWER
  PERSON WITH:
                       1,086,640
                    ------------------------------------------------------------
                    8  SHARED DISPOSITIVE POWER

                       0
--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,086,640
--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES                                                    |_|

          Not Applicable
--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          4.85%
--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON

          HC
--------------------------------------------------------------------------------

                                       -2-



CUSIP No. 157085101                    13G                    PAGE 3 of 10 PAGES

--------------------------------------------------------------------------------
1         NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

          Directed Services, Inc.
--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                         (a) |_|
          Not Applicable                                                 (b) |_|
--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION

          New York
--------------------------------------------------------------------------------
                    5  SOLE VOTING POWER

                       1,086,640
                    ------------------------------------------------------------
   NUMBER OF        6  SHARED VOTING POWER
    SHARES
 BENEFICIALLY          0
 OWNED BY EACH      ------------------------------------------------------------
   REPORTING        7  SOLE DISPOSITIVE POWER
  PERSON WITH:
                       1,086,640
                    ------------------------------------------------------------
                    8  SHARED DISPOSITIVE POWER

                       0
--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,086,640
--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES                                                    |_|

          Not Applicable
--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          4.85%
--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON

          IC
--------------------------------------------------------------------------------


                                      -3-



CUSIP No. 157085101                    13G                    PAGE 4 of 10 PAGES

ITEM 1(A).        NAME OF ISSUER:

                  Cerus Corporation

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

                  2411 Stanwell Drive
                  Concord, CA 94520

ITEM 2(A).        NAME OF PERSON FILING:

                  ING Groep N.V.
                  Directed Services, Inc.

ITEM 2(B).        ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:

                  ING Groep N.V.:
                  Amstelveenseweg 500
                  1081 KL Amsterdam
                  The Netherlands

                  Directed Services, Inc.:
                  1475 Dunwoody Drive
                  West Chester, PA  19380


ITEM 2(C).        CITIZENSHIP:

                  See item 4 on Page 2
                  See item 4 on Page 3

ITEM 2(D).        TITLE OF CLASS OF SECURITIES:

                  Common Stock



                                      -4-


CUSIP No. 157085101                    13G                    PAGE 5 of 10 PAGES

ITEM 2(E).        CUSIP NUMBER:

                  157085101

ITEM 3.           IF THIS STATEMENT IS FILED PURSUANT TO RULES 13D-1(B), OR
                  13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:
                  (Not Applicable)

         (a)  |_| Broker or dealer registered under Section 15 of the
                  Securities Exchange Act of 1934, as amended (the "Exchange
                  Act");

         (b)  |_| Bank as defined in Section 3(a)(6) of the Exchange Act;

         (c)  |_| Insurance company as defined in Section 3(a)(19) of the
                  Exchange Act;

         (d)  |_| Investment company registered under Section 8 of the
                  Investment Company Act of 1940, as amended (the "Investment
                  Company Act");

         (e)  |_| Investment adviser in accordance with Rule
                  13d-(1)(b)(1)(ii)(E) under the Exchange Act;

         (f)  |_| Employee benefit plan or endowment fund in accordance with
                  Rule 13d-1(b)(1)(ii)(F) under the Exchange Act;

         (g)  |_| Parent holding company or control person in accordance
                  with Rule 13d-1(b)(1)(ii)(G) under the Exchange Act;

         (h)  |_| Savings association as defined in Section 3(b) of the
                  Federal Deposit Insurance Act;

         (i)  |_| Church plan that is excluded from the definition of an
                  investment company under Section 3(c)(14) of the Investment
                  Company Act;

         (j)  |_| Group in accordance with Rule 13d-1(b)(1)(ii)(J) under the
                  Exchange Act.

ITEM 4.           OWNERSHIP.

         (a) Amount beneficially owned:

                  See item 9 on Page 2
                  See item 9 on Page 3

         (b) Percent of class:

                  See item 11 on Page 2
                  See item 11 on Page 3


                                      -5-


CUSIP No. 157085101                    13G                    PAGE 6 of 10 PAGES

         (c) Number of shares as to which such person has:

             (i)  Sole power to vote or to direct the vote:

                  See item 5 on Page 2
                  See item 5 on Page 3

             (ii) Shared power to vote or to direct the vote:

                  See item 6 on Page 2
                  See item 6 on Page 3

           (iii)  Sole power to dispose or to direct the disposition of:

                  See item 7 on Page 2
                  See item 7 on Page 3

            (iv)  Shared power to dispose or to direct the disposition of:

                  See item 8 on Page 2
                  See item 8 on Page 3

ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

                  Not Applicable

ITEM 6.           OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
                  PERSON.

                  Not Applicable

ITEM 7.           IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                  ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT
                  HOLDING COMPANY OR CONTROL PERSON.

                  Not Applicable

ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

                  Not Applicable

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP.

                  Not Applicable


                                      -6-



CUSIP No. 157085101                    13G                    PAGE 7 of 10 PAGES

ITEM 10.          CERTIFICATION.

                  By signing below we certify that, to the best of our knowledge
                  and belief, the securities referred to above were not acquired
                  and are not held for the purpose of or with the effect of
                  changing or influencing the control of the issuer of the
                  securities and were not acquired and are not held in
                  connection with or as a participant in any transaction having
                  that purpose or effect.



                                      -7-


CUSIP No. 157085101                    13G                    PAGE 8 of 10 PAGES


                                    SIGNATURE


         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                        February 13, 2006
                                        ----------------------------------------
                                        (Date)


                                        ING GROEP N.V.


                                        By:

                                        /s/ Cornelis Blokbergen
                                        ----------------------------------------
                                        (Signature)

                                        Cornelis Blokbergen
                                        Head Legal Department
                                        ----------------------------------------
                                        (Name/Title)


                                        /s/ Huib D. ter Haar
                                        ----------------------------------------
                                        (Signature)


                                        Huib D. ter Haar
                                        Group Compliance Officer
                                        ----------------------------------------
                                        (Name/Title)




CUSIP No. 157085101                    13G                    PAGE 9 of 10 PAGES


                                    SIGNATURE


                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.


                                        February 13, 2006
                                        ----------------------------------------
                                        (Date)


                                        Directed Services, Inc.


                                        By:

                                        /s/ Cornelis Blokbergen
                                        ----------------------------------------
                                        (Signature)

                                        Cornelis Blokbergen
                                        Authorized Signatory
                                        ----------------------------------------
                                        (Name/Title)


                                        /s/ Huib D. ter Haar
                                        ----------------------------------------
                                        (Signature)


                                        Huib D. ter Haar
                                        Authorized Signatory
                                        ----------------------------------------
                                        (Name/Title)



CUSIP No. 157085101                    13G                   PAGE 10 of 10 PAGES


                            Exhibit A to Schedule 13G

                             Joint Filing Agreement
                            Pursuant to Rule 13d-1(k)

                  The undersigned persons (the "Reporting Persons") hereby agree
that a joint statement on this Schedule 13G, and any amendments thereto, be
filed on their behalf by ING Groep N.V.

                  Each of the Reporting Persons is responsible for the
completeness and accuracy of the information concerning each of them contained
therein, but none of the Reporting Persons is responsible for the completeness
or accuracy of the information concerning any other Reporting Person.


Date:  February 13, 2006




                                           ING Groep N.V.


                                           By: /s/ Cornelis Blokbergen
                                               ---------------------------------
                                               Name:   Cornelis Blokbergen
                                               Title:  Head Legal Department


                                           By: /s/ Huib D. ter Haar
                                               ---------------------------------
                                               Name:   Huib D. ter Haar
                                               Title:  Group Compliance Officer


                                            Directed Services, Inc.


                                            By: /s/ Cornelis Blokbergen
                                                --------------------------------
                                                Name:   Cornelis Blokbergen
                                                Title:  Authorized Signatory


                                            By: /s/ Huib D. ter Haar
                                                --------------------------------
                                                Name:   Huib D. ter Haar
                                                Title:  Authorized Signatory