SECURITIES AND EXCHANGE COMMISSION

                              Washington, DC 20549

                         -------------------------------

                                   FORM 8-K/A

                               AMENDMENT NO. 1 TO

                                 CURRENT REPORT

                       PURSUANT TO SECTION 13 OR 15(D) OF

                       THE SECURITIES EXCHANGE ACT OF 1934

         Date of report (Date of earliest event reported): May 20, 2002
                                                           ------------


                               CYTOGEN CORPORATION
                               -------------------
               (Exact Name of Registrant as Specified in Charter)


             Delaware                   000-14879                  222322400
--------------------------------------------------------------------------------
(State or Other Jurisdiction    (Commission File Number)        (IRS Employer
     of Incorporation)                                       Identification No.)


600 College Road East, CN 5308, Princeton, NJ                         08540
--------------------------------------------------------------------------------
(Address of Principal Executive Offices)                            (Zip Code)



                                 (609) 750-8200
                ------------------------------------------------
                         (Registrant's telephone number,
                              including area code)



          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)





         Item 4.           Changes in Registrant's Certifying Accountant.

         Cytogen Corporation (the "Company") hereby amends its Current Report on
Form 8-K dated May 20, 2002 as filed with the Securities and Exchange Commission
on May 20, 2002 (the "Form 8-K") to revise  certain  disclosure  in the Form 8-K
and to file an amended letter from Arthur Andersen LLP ("Arthur  Andersen") with
respect  thereto.  As reported by the Company in the Form 8-K, on May 20,  2002,
the Company's Board of Directors,  upon  recommendation  of the Audit Committee,
informed  Arthur  Andersen  that  they  would  be  dismissed  as  the  Company's
independent public accountants effective as of May 20, 2002 and engaged KPMG LLP
("KPMG") to serve as the Company's independent public accountants for the fiscal
year ending December 31, 2002. The appointment of KPMG was effective immediately
upon the dismissal of Arthur Andersen.

         Arthur  Andersen's  prior  audit  report  on  the  Company's  financial
statements  for each of the two most  recent  fiscal  years in the period  ended
December 31, 2001 contained no adverse  opinion or disclaimer of opinion and was
not  qualified  or  modified  as to  uncertainty,  audit  scope,  or  accounting
principles. During the Company's two most recent fiscal years ended December 31,
2001, and the subsequent  interim period through May 20, 2002, no  disagreements
between the Company and Arthur  Andersen on any matter of accounting  principles
or practices,  financial statement  disclosure,  or auditing scope or procedure,
which disagreements,  if not resolved to Arthur Andersen's  satisfaction,  would
have caused  Arthur  Andersen  to make  reference  to the subject  matter of the
disagreement in connection with its reports;  and during such periods there were
no reportable  events of the kind listed in Item 304(a)(1)(v) of Regulation S-K.
An amended letter from Arthur Andersen  addressed to the Securities and Exchange
Commission  stating their agreement with the above statements is attached hereto
as Exhibit 16.1.

         During the Company's  two most recent  fiscal years ended  December 31,
2001,  and through May 20, 2002, the Company did not consult with KPMG regarding
any of the  matters  or  events  set  forth  in  Item  304(a)(2)(i)  or  (ii) of
Regulation S-K.

         Item 7.  Financial Statements, Pro Forma Financial Information and
Exhibits.

         (c) Exhibits.

               Exhibit No.     Description of Exhibits
               -----------     -----------------------

               16.1            Amended Letter from Arthur Andersen LLP regarding
                               change in certifying accountant.

               99.1            Press Release disclosing change in certifying
                               accountant issued May 20, 2002,  incorporated
                               herein  by  reference   from  the   Company's
                               Current  Report  on Form  8-K  dated  May 20,
                               2002,  as  filed  with  the   Securities  and
                               Exchange Commission on May 20, 2002.




                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                    CYTOGEN CORPORATION



                                                    By: /s/ Lawrence R. Hoffman
                                                        ------------------------
                                                        Lawrence R. Hoffman,
                                                         Chief Financial Officer


Date:  May 22, 2002