Filed Pursuant to Rule 424(b)(3) and (c)

Registration No. 333-99067

PROSPECTUS SUPPLEMENT NO. 11

(TO PROSPECTUS DATED SEPTEMBER 19, 2002)

HEALTH CARE PROPERTY INVESTORS, INC.

1,477,846 SHARES OF COMMON STOCK(1)

This Prospectus Supplement No. 11 supplements and amends the Prospectus dated September 19, 2002, as previously amended (the “Prospectus”), relating to the possible issuance of our common stock, from time to time, to the holders of non-managing member units in HCPI/Utah II, LLC and the possible resale of shares of our common stock by these holders.  The information in this Prospectus Supplement has been obtained from the selling holder listed herein.  This Prospectus Supplement should be read in conjunction with the Prospectus.

The information appearing in the table below, as of the date hereof, supplements and amends the information in the table appearing under the heading “Selling Holders” in the Prospectus:

 

 

Non-Managing

 

 

 

 

 

 

 

 

 

Member Units of

 

Common

 

 

 

 

 

 

 

HCPI/Utah II,

 

Stock

 

 

 

 

 

 

 

LLC

 

Beneficially

 

 

 

Common Stock

 

 

 

Owned of

 

Owned

 

 

 

Beneficially Owned

 

 

 

Record Prior to

 

Following

 

Common Stock

 

Following the Offering

 

 

 

the

 

the Exchange

 

Offered

 

(1) (2)(3)(5)

 

Name

 

Exchange (2) (3)

 

(1)(2)(3)(4)

 

Hereby(1)(3)

 

Shares

 

Percent

 

 

 

 

 

 

 

 

 

 

 

 

 

The Corporation of the President of The Church of Jesus Christ of Latter-day Saints

 

1,850

 

3,700

 

3,700

 

0

 

*

 

 

*  Represents less than 1% of the total outstanding shares of our common stock.

(1)                                  Reflects the adjustment for the 2-for-1 stock split in the form of a stock dividend on issued and outstanding shares of Health Care Property Investors, Inc. (the “Corporation”) common stock that was paid immediately after the close of business on March 1, 2004 to holders of record of the common stock of the Corporation at the close of business on February 4, 2004.

(2)                                  Based on information provided to us by the holder of non-managing member units as of July 10, 2006.

(3)                                  The Corporation of the President of The Church of Jesus Christ of Latter-day Saints obtained 1,850 non-managing member units of HCPI/Utah II, LLC in an assignment from Lonnie M. Bullard, a selling holder in the Prospectus.

(4)                                  Assumes the selling holder exchanges all of the non-managing member units of HCPI/Utah II, LLC beneficially owned by it for shares of the Corporation’s common stock.  Also assumes that no transactions with respect to our common stock or the non-managing member units occur other than the exchange or the exchange and the offering, as applicable.

(5)                                  Contemplates the sale of all of the common stock offered hereby.

Investing in our common stock involves a high degree of risk.  Please consider the “Risk Factors” beginning on page 1 of the Prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this Prospectus Supplement is July 31, 2006.