Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Miksztal Andrew
 2. Date of Event Requiring Statement (Month/Day/Year)
01/01/2006		 3. Issuer Name and Ticker or Trading Symbol
DURECT CORP [DRRX]
(Last)
(First)
(Middle)
10240 BUBB ROAD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP Pharmaceutical R&D
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CUPERTINO, CA 95014		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 6,145
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Incentive Stock Option (right to buy) 06/26/2003(1) 02/10/2013 Common Stock 12,825 $ 1.58 D  
Incentive Stock Option (right to buy) 02/10/2004(2) 02/10/2013 Common Stock 12,825 $ 1.58 D  
Incentive Stock Option (right to buy) 02/27/2005(2) 02/27/2014 Common Stock 28,000 $ 2.51 D  
Incentive Stock Option (right to buy) 12/17/2005(3) 12/17/2014 Common Stock 26,497 $ 3.2 D  
Incentive Stock Option (right to buy) 09/05/2001(2) 09/05/2010 Common Stock 8,000 $ 6 D  
Incentive Stock Option (right to buy) 02/11/2003(2) 02/11/2012 Common Stock 16,000 $ 9.19 D  
Incentive Stock Option (right to buy) 01/02/2002(2) 01/02/2011 Common Stock 10,000 $ 11.125 D  
Non-Qualified Stock Option (right to buy) 12/17/2005(3) 12/17/2014 Common Stock 3,503 $ 3.2 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Miksztal Andrew
10240 BUBB ROAD
CUPERTINO, CA 95014		       VP Pharmaceutical R&D  

Signatures

Andrew Miksztal 01/03/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares subject to this option will begin vesting on June 26, 2003 and will vest as follows: (i) 20 percent on June 26, 2003, (ii) 10 percent on 12/31/2003, (iii) 7.5 percent on 2/10/2006, (iv) 12.5 percent on 2/10/2007, (v) 12.5 percent on 2/10/2008, (vi) 12.5 percent on 2/10/2009, (vii) 12.5 percent on 2/10/1010, and (viii) 12.5 percent on 2/10/2011.
(2) Vesting Commencement Date. Vests at the rate of 1/4 of the underlying securities will vest on each 12-month anniversary of the Grant Date.
(3) NQ/ISO Grants Dated December 17, 2004 combined will vest as follows: 1/4 of the underlying securities will vest on each 12-month anniversary of the Grant Date.

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