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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549

                                   FORM 10QSB



[ X ]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended:             March 31, 2004
                                 ----------------------------------------------


                                       OR

[    ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                       to
                               ------------------------------------------------

Commission file number:             0-22319
                         ------------------------------------------------------

                            PATIENT INFOSYSTEMS, INC.
                            -------------------------
             (Exact name of registrant as specified in its charter)

          Delaware                                   16-1476509
          --------                                   ----------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
incorporation or organization)

                      46 Prince Street, Rochester, NY 14607
                      -------------------------------------
                    (Address of principal executive offices)

                                 (585) 242-7200 (Registrant's telephone number,
              including area code)

     Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the last 90 days. Yes [X] No [ ]

     As of May 15, 2004, 6,024,979 shares of the Company's common stock, par
value $0.01 per share, were outstanding.

     Transitional Small Business Disclosure Format (check one) Yes [ ] No [X]


--------------------------------------------------------------------------------






PART I. FINANCIAL INFORMATION
Item 1. Consolidated Financial Statements


PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
CONSOLIDATED BALANCE SHEETS (UNAUDITED) AS OF

ASSETS                                                                     March 31, 2004 December 31, 2003
                                                                           --------------  ----------------
CURRENT ASSETS:
                                                                                    
  Cash and cash equivalents                                                $     703,527  $    397,851
  Accounts receivable                                                            878,505       771,258
  Prepaid expenses and other current assets                                      156,900       156,729
                                                                           -------------- -------------
        Total current assets                                                   1,738,932     1,325,838

Property and equipment, net                                                      297,093       305,551

OTHER ASSETS:
  Intangible assets
    (net of accumulated amortization of $633,859 and $586,830)                   438,900       497,893
  Goodwill                                                                     7,004,625     6,981,876
                                                                           -------------- -------------

TOTAL ASSETS                                                               $  9,479,550   $  9,111,158
                                                                           ============== =============

LIABILITIES AND STOCKHOLDERS' DEFICIT

CURRENT LIABILITIES:
  Bank overdraft                                                                 $     -     $ 189,608
  Accounts payable                                                             1,282,552     1,337,862
  Accrued salaries and wages                                                     518,832       442,299
  Accrued expenses                                                               852,758     1,043,247
  Accrued dividends                                                              699,790       490,756
  Current maturities of long-term debt                                            64,795       294,117
  Deferred revenue                                                               105,689       336,598
                                                                           -------------- -------------
        Total current liabilities                                              3,524,416     4,134,487
                                                                           -------------- -------------

LINE OF CREDIT                                                                 3,000,000     3,000,000
LONG-TERM DEBT                                                                    34,098        40,295

STOCKHOLDERS' DEFICIT:
  Preferred stock - $.01 par value:  shares authorized: 20,000,000
    Series C, 9% cumulative, convertible, issued and outstanding - 75,000
       as of March 31, 2004, 100,000 as of December 31, 2003                         750         1,000
    Series D, 9% cumulative, convertible, issued and outstanding - 840,118
       as of March 31, 2004, 830,100 as of December 31, 2003                       8,401         8,301
  Common stock - $.01 par value:  shares authorized:
     80,000,000; issued and outstanding - 6,024,979 as of March 31, 2004,
        4,960,354 as of December 31, 2003                                         60,250        49,604
  Additional paid-in capital                                                  48,334,726    45,596,684
  Unearned debt issuance cost                                                   (914,000)         -
  Accumulated deficit                                                        (44,569,091)  (43,719,213)
                                                                           -------------- -------------
        Total stockholders' deficit                                            2,921,036     1,936,376
                                                                           -------------- -------------

TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT                                $   9,479,550  $  9,111,158
                                                                           ============== =============

See notes to unaudited consolidated financial statements.






PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES


CONSOLIDATED STATEMENTS OF OPERATION (UNAUDITED)
                                             Three Months Ended
                                                 March 31,
                                            2004            2003
                                            ----            ----

REVENUES
                                                 
  Disease and Demand Management Fees   $   2,344,427   $   947,679
  Ancillary Benefits Management Fees       1,676,510          -
                                       -------------- -------------
       Total revenues                      4,020,937       947,679
                                       -------------- -------------
COSTS AND EXPENSES
  Cost of sales                            3,170,705       761,602
  Sales and marketing                        371,122       242,603
  General and administrative               1,016,861       275,469
  Research and development                    32,607        31,758
                                       -------------- -------------
        Total costs and expenses           4,591,295     1,311,432
                                       -------------- -------------
OPERATING LOSS                              (570,358)     (363,753)
OTHER EXPENSE
  Financing Cost                            (171,375)         -
  Interest expense, net                      (29,966)     (141,453)
                                       -------------- -------------
NET LOSS                                    (771,699)     (505,206)

CONVERTIBLE PREFERRED STOCK DIVIDENDS       (287,214)      (22,500)
                                       -------------- -------------
NET LOSS ATTRIBUTABLE TO
  COMMON STOCKHOLDERS                  $  (1,058,913)  $  (527,706)
                                       ============== =============
NET LOSS PER SHARE - BASIC
   AND DILUTED                         $       (0.20)  $     (0.58)
                                       ============== =============
WEIGHTED AVERAGE COMMON  SHARES            5,348,800       913,002


See notes to unaudited consolidated financial statements.






PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES


CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
                                                                                      Three Months    Three Months
                                                                                         Ended            Ended
                                                                                     March 31, 2004  March 31, 2003
OPERATING ACTIVITIES:
                                                                                                 
  Net loss                                                                             $ (771,699)     $  (505,206)
  Adjustments to reconcile net loss to net cash used in
    operating activities:
      Depreciation and amortization                                                        280,687          82,138
      Compensation expense related to warrants                                             223,088            -
      (Increase) decrease in accounts receivable                                          (107,247)         87,946
      (Increase) decrease in prepaid insurance, expenses and other current assets             (171)          2,642
      Decrease in accounts payable                                                         (55,310)        (45,449)
      Increase in accrued salaries and wages                                                76,533          78,562
      (Decrease) increase in accrued expenses                                             (190,489)        128,815
      Decrease in deferred revenue                                                        (230,909)        (31,800)
                                                                                     -------------- ---------------
            Net cash used in operating activities                                         (775,517)       (202,352)
                                                                                     -------------- ---------------
INVESTING ACTIVITIES:
  Property and equipment additions                                                         (41,860)        (18,572)
  Increase in notes receivable                                                                -           (300,000)
                                                                                     -------------- ---------------
          Net cash used in investing activities                                            (41,860)       (318,572)
                                                                                     -------------- ---------------

FINANCING ACTIVITIES:
  Borrowing from directors, net                                                               -            600,000
  Decrease in bank overdraft                                                              (189,608)
  Payment of debt                                                                         (235,519)           -
  Proceeds from the sale of common stock                                                 1,663,180            -
  Expenses related to the sale of common stock                                            (115,000)           -
                                                                                     -------------- ---------------
            Net cash provided by financing activities                                    1,123,053         600,000
                                                                                     -------------- ---------------
NET INCREASE IN CASH AND CASH  EQUIVALENTS                                                 305,676          79,076

CASH AND CASH EQUIVALENTS AT  BEGINNING OF PERIOD                                          397,851           5,011
                                                                                     -------------- ---------------
CASH AND CASH EQUIVALENTS AT  END OF PERIOD                                             $  703,527        $ 84,087
                                                                                        ===========       ========

Supplemental disclosures of non-cash information
  Dividend declared on Convertible Preferred Stock                                      $  209,034        $ 22,500
                                                                                        ===========       ========
  Beneficial conversion feature of Convertible Preferred Stock                          $   78,180
                                                                                        ==========
  Fair market value of:
    Warrants issued as an expense of sale of Common Stock                               $   46,625
                                                                                        ==========
    Warrants issued as acquisition expense                                              $   22,750
                                                                                        ==========
    Warrants issued or debt guarantee                                                   $1,085,375
                                                                                        ==========
    Common Stock issued for services                                                    $   44,250
                                                                                        ==========


See notes to unaudited consolidated financial statements.






PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES


     Notes to Unaudited  Consolidated  Financial Statements for the period ended
March 31, 2004

1.   The consolidated  financial  statements include the accounts of the Company
     and its wholly owned subsidiaries,  Patient Infosystems Canada, Inc., which
     ceased operations in January 2001 and American  Caresource  Holdings,  Inc.
     ("ACS")  which was  created  in  December  2003.  Significant  intercompany
     transactions and balances have been eliminated in consolidation.

     Acquisition - On December 31, 2003, the Company acquired  substantially all
     the assets and liabilities of American  Caresource  Corporation for a total
     purchase price of $5,754,866.  The Company recorded this acquisition  using
     the purchase method of accounting and therefore,  the operations of ACS are
     included only since the date of the acquisition.

     The  accompanying  consolidated  financial  statements  for the three month
     periods  ended March 31, 2004 and March 31, 2003 are  unaudited and reflect
     all adjustments  (consisting  only of normal recurring  adjustments)  which
     are, in the opinion of management, necessary for a fair presentation of the
     financial  position and operating  results for the interim  periods.  These
     unaudited  consolidated  financial statements should be read in conjunction
     with the  audited  consolidated  financial  statements  and notes  thereto,
     together with management's  discussion and analysis of financial  condition
     and results of operations  contained in the Company's Annual Report on Form
     10-KSB for the year ended December 31, 2003. Certain  reclassifications  of
     2003 amounts have been made to conform to 2004  presentations.  The results
     of operations for the three months ended March 31, 2004 are not necessarily
     indicative of the results for the entire year ending December 31, 2004.

     All share and per share information  contained herein gives effect to the 1
     for 12 reverse stock split which was effective as of January 9, 2004.

     The  calculations  for the basic and  diluted  loss per share for the three
     month periods  ended March 31, 2004 and 2003 did not include  1,527,160 and
     92,877,  respectively,  options to purchase  shares of common stock nor the
     common  equivalent  shares  issuable  upon  conversion  of the  100,000 and
     915,188,  respectively,  shares of preferred  stock which were  outstanding
     because  the  effect  would have been  antidilutive  due to the net loss in
     those periods.  The  computation of basic and diluted net loss per share is
     as follows:



                                                    Three Months Ended
                                                        March 31,
                                                   2004              2003
                                                   ----              ----
                                                           
     Net loss                                 $   (771,699)      $ (505,206)

     Convertible preferred Stock dividends        (287,214)         (22,500)
                                              -------------      -----------
     Net loss attributable to
          Common Stockholders                 $ (1,085,913)      $ (527,706)
                                              -------------      -----------
     Weighted average common shares              5,348,800          913,002
                                              -------------      -----------
     Net loss per share - Basic and diluted   $      (0.20)      $    (0.58)
                                              =============      ===========


     Stock-Based  Compensation  - In 2002,  the  Company  adopted  Statement  of
     Financial   Accounting   Standards   ("SFAS")  No.  148,   "Accounting  for
     Stock-Based  Compensation  -  Transition  and  Disclosure."  This  standard
     provides alternative methods of transition for voluntary change to the fair
     value based method of accounting  for  stock-based  employee  compensation.
     Additionally,  the standard  also  requires  prominent  disclosures  in the
     Company's  financial  statements  about the method of  accounting  used for
     stock-based employee  compensation,  and the effect of the method used when
     reporting financial statements.

     The Company  accounts for stock-based  compensation in accordance with SFAS
     No. 123,  "Accounting for Stock-Based  Compensation".  As permitted by SFAS
     No. 123, the Company continues to measure compensation for such plans using
     the intrinsic  value based method of  accounting,  prescribed by Accounting
     Principles Board ("APB"),  Opinion No. 25,  "Accounting for Stock Issued to
     Employees."   Had   compensation   cost  for  the   Company's   stock-based
     compensation  plans been determined  based on the fair value at the date of
     grant for  awards  consistent  with the  provisions  of SFAS No.  123,  the
     Company's net loss and net loss per share would have been  increased to the
     pro forma amounts indicated below:



                                            Three Months Ended
                                                March 31,
                                           2004           2003
                                           ----           ----
     Net loss attributable to common
                                                 
     shareholders - as reported         $1,058,913)    ($527,706)

     Stock compensation expense         (1,161,959)      (26,334)
                                        ------------ -------------
     Net loss - pro forma               (2,220,872)     (554,040)

     Net loss per share - basic
       and diluted - as reported            ($0.20)       ($0.58)
                                        ============ =============
     Net loss per share - basic
       and diluted - pro forma              ($0.42)       ($0.61)
                                        ============ =============
     Weighted average common shares      5,348,800       913,002



     The fair value of each option grant is estimated on the date of grant using
     the Black-Scholes  option-pricing model using an assumed risk-free interest
     rates of 3.31% for the three month period  ended March 31, 2004,  3.79% for
     the year ended  December  31,  2003 and an  expected  life of 7 years.  The
     assumed  dividend yield was zero. The Company has used a volatility  factor
     of 113% for the three  month  period  ended  March 31, 2004 and 98% for the
     year ended  December 31, 2003.  For purposes of pro forma  disclosure,  the
     estimated  fair value of each  option is  amortized  to  expense  over that
     option's  vesting period and only the  compensation  expense related to the
     three month  periods  ended March 31, 2003 and 2004 were used to adjust the
     net loss on a pro forma basis.

2.   On December 31, 2003,  the Company  entered into the Third  Addendum to the
     Second  Amended and Restated  Credit  Agreement  with Well Fargo Bank Iowa,
     N.A., which extended the term of the $3,000,000 credit facility to July 31,
     2005. Dr. Schaffer and Mr. Pappajohn,  directors of the Company, guaranteed
     this extension. In consideration of their guarantees,  in February 2004 the
     Company granted to Dr. Schaffer and Mr.  Pappajohn  warrants to purchase an
     aggregate  of  47,500  shares  of  Series D  Convertible  Preferred  Stock,
     convertible  into 475,000  shares of the Company's  common Stock for $10.00
     per preferred  share. The Company valued these warrants at $1,085,375 using
     the  Black-Scholes  method.  The value of these  warrants  was  recorded as
     unearned debt issuance costs and will be amortized as financing  costs over
     the nineteen month period of the loan guarantee.  During the 3 months ended
     March 31, 2004, the company recorded a financing cost of $171,375.

3.   On March 28, 2004, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
     Company in which they made a commitment to obtain the operating  funds that
     the Company  believes  would be sufficient to fund its  operations  through
     January 1, 2005. There can be no assurances given that Mr. Pappajohn or Dr.
     Schaffer can raise either the required  working capital through the sale of
     the  Company's  securities  or that the Company  can borrow the  additional
     amounts needed.

4.   During the three month  period  ended March 31,  2004,  the Company  issued
     814,625  shares  of its  Common  Stock and  4,700  shares  of its  Series D
     Convertible Preferred Stock to certain investors in exchange for $1,663,180
     which  consisted  of  $1,610,000  of  working  capital,  $53,180 of accrued
     interest payable and $44,250 of services.  The Company incurred $205,875 of
     costs directly attributable to the sale of its common stock.

     During the three month  period  ended  March 31,  2003,  the  Company  paid
     $113,625 of expenses by issuing  shares of its Common Stock and warrants to
     purchase  shares of its Common Stock.  The Company  issued 22,125 shares of
     its Common  Stock as payment of $44,250 in  consulting  expenses and issued
     warrants to purchase  25,000  shares of its Common Stock at $2.75 per share
     that were  assigned a fair market  value of $69,375  using a  Black-Scholes
     valuation method.

     Of the warrants to purchase  25,000 shares of the  Company's  Common Stock,
     warrants  to purchase  12,500  shares  assigned a value of $22,750  were an
     additional  expense related to the purchase of substantially all the assets
     of and assumption of liabilities  from American  Caresource  Corporation on
     December 31, 2003.  Accordingly,  goodwill  related to this acquisition was
     increased by $22,750.

5.   During the three  months  ended March 31, 2004 the Company  operated in two
     segments: (i) Patient Infoystems, which includes disease management, demand
     management and provider improvement services; and (ii) American Caresource,
     which includes ancillary benefits management  services.  Selected financial
     information  on the  Company's  segments for the three month  periods ended
     March 31, 2004 and 2003 and pro forma  combined as if the  acquisition  had
     occurred as of January 1, 2003 are presented as follows:



                                                                      March 31,
                                                        2004              2003             2003
                                                                                         Pro Forma
     Revenues
                                                                               
      Patient Infosystems, Inc.                      $    2,344,427     $    947,679    $     947,679
      American Caresource Holdings, Inc.                  1,676,510             -           2,581,617
                                                 ------------------- ---------------- ----------------
     Total revenue                                        4,020,937          947,679        3,529,296

     Cost of goods
      Patient Infosystems, Inc.                           1,526,595          761,602          761,602
      American Caresource Holdings, Inc.                  1,644,110             -           2,999,403

     Selling, General and Administrative
      Patient Infosystems, Inc.                             601,792          549,830          549,830
      American Caresource Holdings, Inc.                    818.798             -             657,391

     Other
      Patient Infosystems, Inc.                             196,772          141,453          141,453
      American Caresource Holdings, Inc.                      4,569             -               5,458
                                                 ------------------- ---------------- ----------------
     Net profit (loss)
      Patient Infosystems, Inc.                              19,268         (505,206)        (505,206)
      American Caresource Holdings, Inc.                   (790,967)            -          (1,080,635)
                                                 ------------------- ---------------- ----------------
     Total net loss                                        (771,699)        (505,206)      (1,585,841)

     Dividends                                             (287,214)         (22,500)        (170,958)
                                                 ------------------- ---------------- ----------------
     Net loss attributable to
      common shareholders                                (1,058,913)        (527,706)      (1,756,799)
                                                 =================== ================ ================
     Net loss per share basic and diluted               $     (0.20)      $    (0.58)      $    (1.92)
                                                 =================== ================ ================
     Weighted average common shares                       5,348,800          913,002          913,002
                                                 =================== ================ ================


6.   The  accompanying  unaudited  consolidated  financial  statements have been
     prepared on a going concern basis,  which  contemplates  the realization of
     assets  and  the  satisfaction  of  liabilities  in the  normal  course  of
     business.  As shown in the accompanying  unaudited  consolidated  financial
     statements,  the  Company  incurred a net loss for the three  month  period
     ended  March 31,  2004 of  $771,699  and had  negative  working  capital of
     $1,785,484 at March 31, 2004.  These  factors,  among others,  may indicate
     that the  Company  will be  unable to  continue  as a going  concern  for a
     reasonable period of time.

     The  unaudited   consolidated  financial  statements  do  not  include  any
     adjustments  relating to the recoverability of assets and classification of
     liabilities  that  might be  necessary  should  the  Company  be  unable to
     continue as a going concern.  The Company's  ability to continue as a going
     concern is dependant upon its ability to generate  sufficient  cash flow to
     meet its  obligations.  Management  is currently  assessing  the  Company's
     operating   structure  for  the  purpose  of  reducing  ongoing   expenses,
     increasing  sources of revenue and is  negotiating  the terms of additional
     debt or equity financing.



Item 2. Management's  Discussion and Analysis of Financial Condition and Results
     of Operations.

     Management's  discussion  and analysis  provides a review of the  Company's
operating results for the three month period ended March 31, 2004 as compared to
the  three  month  period  ended  March 31,  2003 and a review of the  Company's
financial condition at March 31, 2004 as compared to March 31, 2003 and December
31, 2003.  The focus of this review is on the  underlying  business  reasons for
significant  changes  and  trends  affecting  the  revenues,  net  earnings  and
financial  condition of the Company.  This review should be read in  conjunction
with the accompanying unaudited consolidated financial statements.

     In an effort to give investors a well-rounded  forward-looking  view of the
Company's current condition and future  opportunities,  this Quarterly Report on
Form 10-QSB  includes  information  from the Company's  management  about future
performance  and results.  Because they are  forward-looking,  this  information
involves  uncertainties.  These  uncertainties  include the Company's ability to
continue its operations as a result of, among other things,  continuing  losses,
working capital short falls,  uncertainties  with respect to sources of capital,
risks of market  acceptance  of or  preference  for the  Company's  systems  and
services,  competitive forces, the impact of changes in government  regulations,
general economic factors in the healthcare  industry and other factors discussed
in the Company's filings with the Securities and Exchange  Commission  including
the Company's Annual Report on Form 10-KSB for the year ended December 31, 2003.

     To assist the reader's understanding the results of operations, each of the
Company's  segments will be presented  separately using the following  segmented
statement of operations, which includes pro forma results of American Caresource
Holdings,  Inc. for the three month period ended March 31, 2003 for  comparative
purposes:



                                                Patient Infosystems               American Caresource
                                                Three Months Ended                 Three Months Ended
                                                     March 31,                         March 31,
                                               2004              2003            2004             2003
                                               ----              ----            ----             ----
                                                                                                Pro forma
                                                                                
REVENUES                                  $  2,344,427      $  947,679      $ 1,676,510     $  2,581,617
COSTS AND EXPENSES
  Cost of sales                              1,526,595         761,602        1,644,110        2,999,403
  Sales and marketing                          222,010         242,603          149,112           68,228
  General and administrative                   347,175         275,469          669,686          589,163
  Research and development                      32,607          31,758
                                         -------------- --------------- ---------------- ----------------
        Total costs and expenses             2,128,387       1,311,432        2,462,908        3,656,794
OPERATING PROFIT (LOSS)                        216,040        (363,753)        (786,398)      (1,075,177)
OTHER EXPENSE                                 (196,772)       (141,453)          (4,569)          (5,458)
                                         -------------- --------------- ---------------- ----------------
NET PROFIT (LOSS)                               19,268        (505,206)        (790,967)      (1,080,635)


Results of Operations

     PATIENT INFOSYSTEMS

     Revenues

     Revenues  consist of revenues  from  operations  and other  fees.  Revenues
increased to $2,344,427  from  $947,679  during the three months ended March 31,
2004 and 2003, respectively, or 147%.



                                       Three Months Ended
                                            March 31,
Revenues                              2004             2003
--------                              ----             ----
Operations fees
                                             
  Provider improvement            $ 1,858,103      $ 369,996
  Disease and demand management       483,638        549,307
                                -------------- --------------
Total operations fees               2,341,741        919,303
Other fees                              2,686         28,376
                                -------------- --------------

Total revenues                    $ 2,344,427      $ 947,679
                                -------------- --------------


     Provider   innovations   and   improvement   fee  revenues  are   primarily
attributable  to  assistance   provided  to  organizations   for  the  effective
management of patients with chronic disease,  including  information  technology
support,  learning organization services, and data analysis and reporting. For a
substantial  part of its innovation and improvement  work,  Patient  Infosystems
participates in as a subcontractor to the Institute for Healthcare  Improvement.
Provider  improvement fee revenues  increased to $1,858,103 for the three months
ended March 31, 2004 as compared to $369,996  for the three  months  ended March
31, 2003. No assurances can be given that Patient  Infosystems  will continue to
provide these services at the current levels, or at all, and revenue  recognized
during the three month period ended March 31, 2004 is not necessarily indicative
of the results to be expected for the entire year ending  December 31, 2004. The
contracts for substantially all the provider  improvement services are annual in
nature,  the largest of which ended as of March 31,  2004.  Patient  Infosystems
anticipates  renewing this contract and is therefore continuing to provide these
services  during the renewal  process.  No  assurance  can be given that Patient
Infosystems can successfully renew the contract.

     Disease and demand  management fee revenues are primarily  attributable  to
the operation of Patient  Infosystems'  call center and the delivery of the Care
Team Connect for Health directly to patients.  Disease and demand management fee
revenues  decreased to $483,638  from $549,307 for the three month periods ended
March 31, 2004 and 2003,  respectively.  The decrease in these fees is primarily
attributable  to the  termination  of one  customer  on July 1,  2003 for  which
Patient  Infosystems had $160,620 of revenue during the three month period ended
March 31, 2003. Patient Infosystems is actively marketing its Disease and demand
management  services  and  anticipates  continuing  to  sell  its  services.  No
assurances  can be given  that  Patient  Infosystems  will sell its  demand  and
disease  management  services,  if at all,  nor that any such  sales will have a
material effect on the financial status of Patient Infosystems.

     Other fee  revenues  were $2,686 and  $28,376  for the three month  periods
ended March 31, 2004 and 2003, respectively.  Patient Infosystems received other
revenues for (i)  development  fees from a variety of customers for creation of,
or modification to, specific programs and (ii) license fees. Patient Infosystems
has completed substantially all services under these agreements. Development fee
revenues include clinical,  technical and operational  design or modification of
Patient Infosystems'  primary disease management  programs.  Patient Infosystems
anticipates  that revenue from  development  fees will continue to be low unless
Patient Infosystems enters into new development agreements.  Patient Infosystems
has not  entered  into any new  licensing  agreements  and the  revenue  for the
current  period  reflects  revenue  generated   exclusively  from  the  existing
agreements.

     Costs and Expenses

     Cost of sales includes salaries and related benefits,  services provided by
third  parties,  and  other  expenses  associated  with the  implementation  and
delivery of Patient  Infosystems'  provider  improvement  and demand and disease
management programs. Cost of sales for the three months ended March 31, 2004 was
$1,526,595  as compared to $761,602  for the three  months ended March 31, 2003.
The increase in these costs was  primarily  the result of increased  operational
activity.  Patient  Infosystems' gross margin, being total revenues over cost of
sales,  was positive for the three month  periods ended March 31, 2004 and 2003.
Patient  Infosystems  anticipates that revenue must increase for it to recognize
economies of scale  adequate to improve its margins.  No assurance  can be given
that  revenues  will  increase or that, if they do, they will continue to exceed
costs and expenses.

     Sales  and  marketing  expenses  consist  primarily  of  salaries,  related
benefits,  travel costs,  sales materials and other marketing  related expenses.
Sales and  marketing  expenses  for the three  months  ended March 31, 2004 were
$222,010  as compared to $242,603  for the three  months  ended March 31,  2003.
Patient  Infosystems  anticipates  expansion of Patient  Infosystems'  sales and
marketing  staff  and  expects  it will  continue  to  invest  in the  sales and
marketing  process,  and that such  expenses  related to sales and marketing may
increase in future periods.

     General  and  administrative   expenses  include  the  costs  of  corporate
operations,  finance and accounting, human resources and other general operating
expenses of Patient  Infosystems.  General and  administrative  expenses for the
three months ended March 31, 2004 were $347,175, as compared to $275,469 for the
three months  ended March 31, 2003.  These  expenditures  have been  incurred to
maintain the corporate  infrastructure  necessary to support anticipated program
operations.   General  and  administrative   expenses  are  expected  to  remain
relatively constant in future periods..

     Research and development expenses consist primarily of salaries and related
benefits and  administrative  costs  associated  with the development of certain
components of Patient Infosystems'  integrated  information capture and delivery
system,  as well as development  of Patient  Infosystems'  standardized  disease
management  programs  and  Patient   Infosystems's   Internet  based  technology
products. Research and development expenses for the three months ended March 31,
2004 were  $32,607,  as compared to $31,758 for the three months ended March 31,
2003.

     Patient Infosystems recorded other expenses of $196,772 for the three month
period  ended March 31, 2004 as compared to $141,453  for the three month period
ended March 31, 2003,  principally due to the interest expense and other related
financing cost on debt.

     Patient  Infosystems  had a net profit of $19,268 as  compared to a loss of
$505,206 for the 3 month periods ended March 31, 2004 and 2003, respectively.

     AMERICAN CARESOURCE

     Revenues

     Revenues of American  Caresource  Holdings,  Inc.  ("ACS") are comprised of
revenues  from  ancillary  service  claims and  processing  of  patient  claims.
Revenues  decreased to $1.7  million  from $2.6 million  during the three months
ended March 31, 2004 and 2003, respectively, or 35.0%.



                                    Three Months Ended
                                          March 31
         Revenues                2004                 2003
         --------                ----                 ----
                                                   Pro forma
                                             
         Ancillary Health      $1,544,848          $ 2,476,944
         Patient Claims           131,662              104,673
                           ---------------- ------------------
         Total Revenues        $1,676,510          $  2,581,61


     Ancillary  health  claims  revenue  decreased to $1.5 million for the three
months  ended March 31, 2004 as  compared to $2.5  million for the three  months
ended March 31, 2003.  This  decrease is  attributable  to the  cancellation  of
contracts  by major  clients and to the  reduction of revenue from a provider in
ACS' ancillary health provider network. Pinnacol Assurance ("Pinnacol") notified
ACS on  December  19,  2003 of its intent to  terminate  its  contract  with ACS
effective  March 18, 2004, and was winding down  throughout the first quarter of
2004.  Revenue for Pinnacol  decreased  45.4% from $981,269 for the three months
ended March 31, 2003 to $536,035  for the three  months  ended March 31, 2004. A
provider  for which ACS had $314,421 of revenue for the three months ended March
31, 2003, notified ACS of its intent to terminate its contract effective October
13, 2004 and did not  generate any revenue for ACS during the three month period
ended March 31 2004.  ACS expects  relations  with  providers  in its network to
improve as a result of the acquisition by Patient Infosystems.  ACS also expects
to expand  its  provider  network  by  seeking  to  restore  relationships  with
providers previously in the network and add new providers as ACS adds new client
payor contracts.  No assurances can be given that ACS will be able to expand its
provider or payor  relationships,  nor that any such expansion will result in an
improvement in the results of operations of ACS.

     The processing of patient claims  revenues  increased 25.8% to $131,662 for
the three  months  ended March 31,  2004 as  compared to $104,673  for the three
months  ended  March 31,  2003.  The  Company  does not expect to  increase  its
revenues from claims processing in future periods.

     Costs and Expenses

     Cost of revenues includes provider  payments,  direct expenses incurred for
providing  services and the related  direct labor and overhead of providing such
services.  ACS is not  liable for costs  incurred  by its  contracted  providers
unless and until these providers obtain approval from the appropriate payors and
provide the contracted services and ACS receives payment from the payors.  Costs
of revenues also include direct expenses to administer claims,  including direct
labor  associated  with  recruitment and  contracting  with providers,  database
maintenance,  data entry of claims,  claims repricing,  fulfillment and overhead
costs.  Costs of revenues  decreased  to  $1,644,110  for the three month period
ended March 31, 2004 as compared to $2,999,403  for the three month period ended
March 31,  2003.  This  decrease  was due to a decrease  in  provider  payments,
renegotiation  of management  fees payable to one client,  and to a reduction in
direct  expenses and  overhead  associated  with the  decrease in claims  volume
related  to  revenue.  Provider  payments  decreased  $815,653  in  relation  to
decreasing  revenues.  Management fees for client ppoNEXT decreased  $127,173 as
contract changes negotiated in July 2003 took effect upon the acquisition of ACS
by Patient Infosystems. Direct expenses and overhead associated with ACS service
provision  decreased  $342,266 as  reductions  were made to personnel  and other
costs to align ACS' cost structure with its claims volume.

     Sales and marketing  expenses  include the salaries and related benefits of
ACS' account development employees,  travel and other costs for those employees,
and sales  materials and other  marketing or sales expenses of ACS.  Commissions
paid to  independent  outside  salespeople  are based directly on net margin per
client.  Payments to providers and all billing and processing of claims expenses
are  included in cost of revenues.  Sales and  marketing  expenses  increased to
$149,112 for the three  months ended March 31, 2004,  as compared to $68,228 for
the three months ended March 31, 2003. The increase was  attributable  primarily
to a $59,480 salary accrual related to the termination on one employee.

     General  and  administrative  expenses  include  the  salaries  and related
benefits  of ACS'  executive  employees,  systems  development  and  finance and
accounting  employees,  travel and other costs for those employees.  General and
administrative  expenses  increased to $669,686 for the three months ended March
31, 2004, as compared to $589,163 for the three months ended March 31, 2003. The
increase was attributable  primarily to a one time warrant  compensation expense
of  $211,900,  offset by a reduction  in legal costs of $62,971 and $60,710 from
reductions  in  personnel  costs  related  to the  consolidation  of  the  human
resources  function  with  Patient  Infosystems  as  well  as  efficiencies  and
reductions in payment processing volume.

     The Company  recorded  net  interest  expense of $4,569 for the three month
period ended March 31, 2004,  as compared to $5,458 for the same period of 2003.
Any  new   financing   arrangements   will  be  made  by  Patient   Infosystems.
Consequently, ACS' interest expense is expected to be minimal in future periods.

     ACS had a net loss of $790,967 for the three month  periods ended March 31,
2004 compared to $1,080,635 for the same period of 2003.

     Income (loss)

     The Company  reported a net loss  attributable  to common  shareholders  of
$1,058,913  as compared to $527,706 for the three month  periods ended March 31,
2004 and 2003, respectively. This represents a loss per share of $0.20 and $0.58
for the same  respective  periods.  The  Company's  loss per share for the three
month  period  ended March 31, 2003,  on a pro forma  basis,  assuming  that the
acquisition  of  substantially  all  the  assets  and  liabilities  of  American
Caresource  Corporation had occurred on January 1, 2003 is $1.92, as compared to
$0.20  loss per share for the same  period of 2004.  During  the 3 months  ended
March 31, 2004,  the company  recorded  $78,180  beneficial  conversion  feature
related to the  issuance of 10,018  shares of the  Company's  Series D Preferred
Stock,  which was recorded as a dividend,  and declared $209,034 of dividends on
the outstanding preferred stock.

     Liquidity and Capital Resources

     At March 31, 2004, the Company had a working  capital deficit of $1,785,484
as compared to  $2,808,649 at December 31, 2003.  Through March 31, 2004,  these
amounts reflect the effects of the Company's  continuing  losses and borrowings.
Since its inception,  the Company has primarily  funded its operations,  working
capital needs and capital expenditures from the sale of equity securities or the
incurrence of debt.

     On March 28, 2003, the Company  entered into an Amended and Restated Credit
Agreement  with Wells  Fargo Bank Iowa,  N.A.,  which  extended  the term of the
Company's $3,000,000 credit facility to January 2, 2004, under substantially the
same terms. Mr. Pappajohn and Dr. Schaffer, directors of the Company, guaranteed
this extension.

     On December 31, 2003,  the Company  entered into the Third  Addendum to the
Second Amended and Restated  Credit  Agreement with Well Fargo Bank Iowa,  N.A.,
which extended the term of the $3,000,000  credit facility to July 31, 2005. Mr.
Pappajohn and Dr. Schaffer guaranteed this extension.  In consideration of their
guarantees,  In  February  2004 the  Company  granted  to Dr.  Schaffer  and Mr.
Pappajohn  warrants  to  purchase  an  aggregate  of  47,500  shares of Series D
Convertible  Preferred  Stock,  convertible into 475,000 shares of the Company's
common Stock for $10.00 per preferred  share.  The Company valued these warrants
at $1,085,375 using the  Black-Scholes  method.  The value of these warrants was
recorded as unearned debt issuance cost and will be amortized as financing costs
over the nineteen month period of the loan guarantee.  During the 3 months ended
March 31, 2004, the company recorded a financing cost of $171,375.

     In January 2004, the Company borrowed $200,000 for working capital from Mr.
Pappajohn  which was repaid in March 2004 using the  proceeds of the sale of the
Company's common stock.

     On March 28, 2004, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
Company in which they made a commitment to obtain the  operating  funds that the
Company  believes would be sufficient to fund its operations  through January 1,
2005.  There can be no assurances  given that Mr.  Pappajohn or Dr. Schaffer can
raise  either the required  working  capital  through the sale of the  Company's
securities or that the Company can borrow the additional amounts needed.

     During the three month  period  ended March 31,  2004,  the Company  issued
814,625  shares of its Common Stock and 4,700 shares of its Series D Convertible
Preferred Stock to certain  investors in exchange for $1,663,180 which consisted
of  $1,610,000  of working  capital,  $53,180 of accrued  interest  payable  and
$44,250  of  services.   The  Company   incurred   $205,875  of  costs  directly
attributable to the sale of its common stock.

     During the three month  period  ended  March 31,  2003,  the  Company  paid
$113,625  of  expenses  by issuing  shares of its Common  Stock and  warrants to
purchase  shares of its Common  Stock.  The Company  issued 22,125 shares of its
Common  Stock as payment of $44,250 in  consulting  expenses  and issued  25,000
warrants to purchase shares of its Common stock which was assigned a fair market
value of $69,375 using a Black-Scholes valuation method.

     Of the warrants to purchase  25,000 shares of the  Company's  Common Stock,
warrants  to  purchase  12,500  shares  assigned  a  value  of  $22,750  were an
additional  expense related to the purchase of  substantially  all the assets of
and assumption of liabilities from American  Caresource  Corporation on December
31, 2003.  Accordingly,  goodwill  related to this  acquisition was increased by
$22,750.

     The  Company has  expended  significant  amounts to expand its  operational
capabilities  including increasing its administrative and technical costs. While
Patient  Infosystems  has both  curtailed its spending  levels and increased its
revenue, to the extent that American Caresource  Holdings,  Inc. revenues do not
increase  substantially,  the Company's'  losses will continue and its available
capital will diminish  further.  The Company's'  operations are currently  being
funded by the sale of equity  securities.  There can be no assurances given that
the Company can raise either the required  working  capital  through the sale of
its securities or that Patient  Infosystems  can borrow the  additional  amounts
needed.  In  such  instance,  if  Patient  Infosystems  is  unable  to  identify
additional  sources  of  capital,  it will  likely be forced to curtail or cease
operations.  As a result  of the  above,  the  Independent  Auditors'  Report on
Patient  Infosystems'  consolidated  financial  statements  for the  year  ended
December  31, 2003  includes  an  emphasis  paragraph  indicating  that  Patient
Infosystems'  recurring  losses from operations  raise  substantial  doubt about
Patient  Infosystems'  ability to continue as a going concern.  The accompanying
consolidated  financial  statements  do not include any  adjustments  that might
result from the outcome of this uncertainty.


     Inflation

     Inflation did not have a significant  impact on the Company's  costs during
the three month  periods  ended March 31, 2004 and March 31,  2003.  The Company
continues  to monitor the impact of  inflation  in order to minimize its effects
through pricing strategies, productivity improvements and cost reductions.

     Forward Looking Statements

     When used in this and in future  filings by the Company with the Securities
and Exchange Commission,  in the Company's press releases and in oral statements
made with the approval of an authorized  executive  officer of the Company,  the
words or phrases "will likely result,"  "expects," "plans," "will continue," "is
anticipated,"  "estimated,"  "project,"  or  "outlook"  or  similar  expressions
(including  confirmations by an authorized  executive  officer of the Company of
any such  expressions  made by a third party with  respect to the  Company)  are
intended  to  identify  "forward-looking  statements"  within the meaning of the
Private Securities  Litigation Reform Act of 1995. The Company wishes to caution
readers not to place undue reliance on any such forward-looking statements, each
of which speak only as of the date made.  Such statements are subject to certain
risks and  uncertainties  that could cause actual  results to differ  materially
from  historical  earnings and those presently  anticipated or projected.  These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital short falls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of, changes in government  regulations,  general  economic factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the Securities and Exchange Commission  including the Company's Annual Report on
Form 10-KSB for the year ended  December 31, 2003. The Company has no obligation
to  publicly  release  the  result  of any  revisions,  which may be made to any
forward-looking  statements to reflect  anticipated or  unanticipated  events or
circumstances occurring after the date of such statements.



Item 3. Controls and Procedures.

     Our management,  with the  participation of our Chief Executive Officer and
Vice  President,  Financial  Planning,  has evaluated the  effectiveness  of our
disclosure  controls  and  procedure  as of March  31,  2004.  Based  upon  this
evaluation,  our Chief Executive Officer and Vice President,  Financial Planning
concluded  that our  disclosure  controls and  procedures  are effective for the
recording, processing,  summarizing and reporting the information the Company is
required to disclose in the reports it files under the  Securities  Exchange Act
of 1934,  within the time periods  specified in the SEC's rules and forms.  Such
evaluation  did not identify any change in our internal  control over  financial
reporting  that  occurred  during  the  quarter  ended  March 31,  2004 that has
materially  affected,  or is reasonably  likely to affect,  our internal control
over financial reporting.

PART II - OTHER INFORMATION

Item 2. Changes in Securities and Use of Proceeds

     Recent Sales of Unregistered Securities

     In January 2004, the Company issued 10,018 shares of Series D 9% Cumulative
Convertible Preferred Stock ("Series D Preferred Stock") in exchange for $25,000
of cash and $53,180 of accrued  interest.  5,318 of these  shares were issued to
Dr.  Schaffer,  a director of the Company.  There was no placement  agent and no
commissions  were paid to any party.  These shares can be converted  into common
stock at a rate of 10 shares of  common  stock to 1 share of Series D  Preferred
Stock. Each share of Series D Preferred Stock has voting rights equivalent to 10
shares of common stock.  The proceeds from this issuance have been used to repay
debt and support the  operations of Patient  Infosystems'  subsidiary,  American
Caresource Holdings, Inc.

     in February  2004,  the Company sold 592,500  shares of common  stock,  for
$1,185,000 to six accredited  investors,  under an exemption  from  registration
pursuant to Section 4(2) and Rule 506 of the Securities  Act of 1933.  There was
$68,250  of fees  paid and a  warrant  to  purchase  12,500  shares  of  Patient
Infosystems  common  stock for $2.00 per share issued in  connection  with these
funds. On May 5, 2004,  Patient  Infosystems  filed a registration  statement on
Form SB-2 for these shares. Patient Infosystems has a best efforts commitment to
have this registration statement become effective by May 24, 2004.

     In March  2004,  the  Company  sold  222,125  shares of common  stock,  for
$400,000  of  cash  and  $44,250  of the  Company's  expense  liability  to four
accredited  investors,  under an exemption from registration pursuant to Section
4(2) and Rule 506 of the Securities Act of 1933.  There was $15,000 of fees paid
in connection  with these funds.  On May 5, 2004,  Patient  Infosystems  filed a
registration statement on Form SB-2 which included these shares.

     Borrowing from directors

     In January 2004, the Company borrowed $200,000 for working capital from Mr.
Pappajohn  which was repaid in March 2004 using the  proceeds of the sale of the
Company's common stock. The loan was a non-interest bearing demand note.



Item 6. Exhibits and Reports on Form 8-K


Exhibit # Description of Exhibits

3.1--   Certificate of Amendment to the Certificate of Incorporation

3.2 *   By-Laws

4.1--   Patient Infosystems, Inc. Amended and Restated Stock Option Plan

4.2 *** Certificate of Designations, Powers, Preferences and Relative,
        Participating, Optional or Other Special Rights, and the Qualifications,
        Limitations Thereof of the Series C Preferred Stock of Patient
        InfoSystems, Inc.

10.20 + Lease Agreement dated as of February 22, 1995 between Patient
        Infosystems and Conifer Prince Street Associates.

10.21 + First Addendum to Lease Agreement dated as of August 22, 1995 between
        Patient Infosystems and Conifer Prince Street Associates.

10.22 + Second Addendum to Lease Agreement dated as of November 17, 1995 between
        Patient Infosystems and Conifer Prince Street Associates.

10.23 + Third Addendum to Lease Agreement dated as of March 28, 1996 between
        Patient Infosystems and Conifer Prince Street Associates.

10.24 + Fourth Addendum to Lease Agreement dated as of October 29, 1996 between
        Patient Infosystems and Conifer Prince Street Associates.

10.25 + Fifth Addendum to Lease Agreement dated as of November 30, 1996 between
        Patient Infosystems and Conifer Prince Street Associates.

10.26 + Sixth Addendum to Lease Agreement dated as of November 24, 1997 between
        Patient Infosystems and Conifer Prince Street Associates.

10.30 ++ Seventh Addendum to Lease Agreement dated as of June 16, 1999 between
        Patient Infosystems and Conifer Prince Street Associates.

10.33 ++ Revolving Note dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.34 ++ Credit Agreement dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.35 ++ Security Agreement dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.36 ++ Arbitration Agreement dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.37 ++ Financing Statement executed by Patient Infosystems and Norwest Bank
        Iowa, National Association.

10.38 ++ First Amendment to Credit Agreement dated as of March 21, 2000 between
        Patient Infosystems and Norwest Bank Iowa, National Association.

10.39 ++ Note Modification Agreement dated as of March 21, 2000 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.41 *** Form of Subscription Agreement dated on or about March 31, 2000
        between Patient Infosystems and John Pappajohn, Derace Schaffer, Gerald
        Kirke and Michael Richards for Series C 9% Cumulative Convertible
        Preferred Stock.

10.42 *** Form of Registration Rights Agreement dated on or about March 31, 2000
        between Patient Infosystems and John Pappajohn, Derace Schaffer, Gerald
        Kirke and Michael Richards for Series C 9% Cumulative Convertible
        Preferred Stock.

10.43 *** Eighth Addendum to Lease Agreement dated as of December 8, 2000
        between Patient Infosystems and Conifer Prince Street Associates.

10.45 *** Amended and Restated Credit Agreement dated as of March 28, 2001
        between Patient Infosystems and Wells Fargo Bank Iowa, National
        Association.

10.46 *** Revolving Note dated as of March 28, 2001 between Patient Infosystems
        and Wells Fargo Bank Iowa, National Association.

10.47 *** Form of Promissory Notes payable to Dr. Schaffer and Mr. Pappajohn.

10.48 *** Form of Security Agreements with Dr. Schaffer and Mr. Pappajohn.

10.49 *** Ninth Addendum to Lease Agreement dated as of January 7, 2002 between
        Patient Infosystems and Conifer Prince Street Associates.

10.50 # Letter of Agreement dated as of March 25, 2002 between Patient
        Infosystems, John Pappajohn and Derace Schaffer.

10.51 # Second Amended and Restated Credit Agreement dated as of March 28, 2002
between Patient Infosystems and Wells Fargo Bank Iowa, National Association.

10.52 # Revolving Note dated as of March 28, 2002 between Patient Infosystems
        and Wells Fargo Bank Iowa, National Association.

10.53 # Security Agreement dated as of March 28, 2002 between Patient
        Infosystems and Wells Fargo Bank Iowa, National Association.

10.54 ## Addendum to Amended and Restated Credit Agreement dated as of June 28,
        2002 between Patient Infosystems and Wells Fargo Bank Iowa, National
        Association.

10.55 ## Agreement for Purchase and Sale of Assets dated as of September 23,
        2002 between Patient Infosystems and American CareSource Corporation.

10.56 ### Tenth Addendum to Lease Agreement dated as of June 24, 2002 between
        Patient Infosystems and Conifer Prince Street Associates.

10.57 ### Eleventh Addendum to Lease Agreement dated as of December 30, 2002
        between Patient Infosystems and Conifer Prince Street Associates.

10.58 ### Letter of Agreement dated as of March 28, 2003 between Patient
        Infosystems, John Pappajohn and Derace Schaffer.

10.59 ### Second Addendum to Second Amended and Restated Credit Agreement dated
        as of March 28, 2003 between Patient Infosystems and Wells Fargo Bank,
        National Association.

10.60 ### Modification Agreement dated as of March 28, 2003 between Patient
        Infosystems and Wells Fargo Bank, National Association.

10.61 ^ Amended and Restated Agreement for the Purchase and Sale of Assets among
        Patient Infosystems, Inc., American Caresource Corporation, formerly
        known as Health Data Solutions, and the Stockholders Signatory hereto,
        dated April 10, 2003.

10.62 ^ Note and Stock Purchase Agreement between Patient Infosystems, Inc. and
        a group of investors, dated April 10, 2003.

10.63 ^ Patient Infosystems, Inc. Series D Convertible Preferred Stock
        Registration Right Agreement dated April 10, 2003.

10.64 ^ Credit Agreement between American Caresource Corporation and Patient
        Infosystems, Inc. dated April 10, 2003.

10.65 ^^ Twelfth Addendum to Lease Agreement dated as of April 28, 2003 between
        Patient Infosystems and Conifer Prince Street Associates.

10.66 ^^ Thirteenth Addendum to Lease Agreement dated as of June 27, 2003
        between Patient Infosystems and Conifer Prince Street Associates.

10.67 ^^^ Amendment No. 1 to the Amended and Restated Agreement for the Purchase
        and Sale of Assets dated as of July 30, 2003 between Patient Infosystems
        and American Caresource Corporation.

10.68 ^^^ Amendment No. 1 to the Note and Stock Purchase Agreement dated as of
        September 11, 2003 between Patient Infosystems and a group of investors.

10.69 ^^^ Amendment No. 1 to the Credit Agreement dated as of July 30, 2003
        between Patient Infosystems and American Caresource Corporation.

10.70 ^^^ Amendment No. 2 to the Amended and Restated Agreement for the Purchase
        and Sale of Assets dated as of October 8, 2003 between Patient
        Infosystems and American Caresource Corporation.

10.71 -- Third Addendum to Second Amended and Restated Credit Agreement dated as
        of December 31, 2003 between Patient Infosystems and Wells Fargo Bank,
        National Association.

10.72-- Form of Securities Purchase Agreement.

31.1    Certification of the Chief Executive Officer pursuant to Section 302 of
        the Sarbanes-Oxley Act of 2002.

31.2    Certification of the Principal Accounting Officer pursuant to Section
        302 of the Sarbanes-Oxley Act of 2002.

32.1    Certification pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.


--   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 30, 2004 and  incorporated
     herein by reference.

*    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Registration  Statement  on Form  S-1  filed  on July 3,  1996  and
     incorporated herein by reference.

**   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Registration  Statement  on  Form  S-8  filed  on May 3,  2000  and
     incorporated herein by reference.

***  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual  Report on Form 10-K filed on April 2, 2001 and  incorporated
     herein by reference.

+    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on April 13, 1999 and  incorporated
     herein by reference.

++   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 30, 2000 and  incorporated
     herein by reference.

#    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on April 10, 2002 and  incorporated
     herein by reference.

##   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-Q  filed on  November  14,  2002 and
     incorporated herein by reference.

###  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 31, 2003 and  incorporated
     herein by reference.

^    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on  Form  10-QSB  filed  on  May  15,  2003  and
     incorporated herein by reference.

^^   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-QSB  filed on  August  15,  2003 and
     incorporated herein by reference.

^^^  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report on Form  10-QSB  filed on  November  14, 2003 and
     incorporated herein by reference.

(b)  The  following  current  reports  on Form 8-K have been filed as of May 15,
     2004:

     On  January  9,  2004,  the  Company  filed a  current  report  on Form 8-K
reporting that on January 9, 2004 a 1-for-12  reverse split was effected for the
Company's  common stock and therefore,  the common stock would trade under a new
ticker symbol PATY.

     On  January  15,  2004,  the  Company  filed a  current  report on Form 8-K
reporting that on December 31, 2003, the Company had acquired  substantially all
the assets and liabilities of American Caresource Corporation.

     On  February  26,  2004,  the  Company  filed a current  report on Form 8-K
providing required Regulation FD disclosure.

     On March 15,  2004,  the Company  amended its current  report on Form 8-K/A
providing  the  required  financial  statements  related to the  acquisition  of
substantially all the assets and liabilities of American Caresource Corporation.

     On March 31, 2004, the Company filed a current report on Form 8-K providing
a copy of a press release  announcing the Company's  earnings for the year ended
December 31, 2003.

     On April 7, 2004,  the Company filed a current report on Form 8-K providing
a copy of a press release announcing a new customer.

     On April 28, 2004, the Company filed a current report on Form 8-K reporting
a change in the Company's  independent  accountants from Deloitte and Touche LLP
to McGladrey and Pullen LLP.



SIGNATURES

In accordance with the requirements of the Securities Exchange Act of 1934, the
registrant caused this report to be signed on its behalf by the undersigned,
thereunto duly authorized.


                                             PATIENT INFOSYSTEMS, INC.


Date: May 17, 2004            By:      /s/Kent A. Tapper
      -------------------              -----------------------------------
                              Name:    Kent A. Tapper
                              Title:   Principal Accounting Officer


Date: May 17, 2004            By:      /s/Roger L. Chaufournier
      -------------------              -----------------------------------
                              Name:    Roger L. Chaufournier
                              Title:   Director, President and
                                       Chief Executive Officer