--------------------------------------------------------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549

                                   FORM 10-QSB



[ X ]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended:             September 30, 2003
                                 -----------------------------------------------


                                       OR

[    ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                       to
                               -------------------------------------------------

Commission file number:             0-22319
                         -------------------------------------------------------

                            PATIENT INFOSYSTEMS, INC.
                            -------------------------
        (Exact name of small business issuer as specified in its charter)

          Delaware                                   16-1476509
          --------                                   ----------
(State or other jurisdiction of            (I.R.S. Employer Identification No.)
incorporation or organization)

                      46 Prince Street, Rochester, NY 14607
                    (Address of principal executive offices)

                                 (585) 242-7200
                           (Issuer's telephone number)

     As of November 13, 2003,  10,956,424  of the Company's  common  stock,  par
value $.01 per share, were outstanding.

     Transitional Small Business Disclosure Format (check one) Yes [ ] No [X]


--------------------------------------------------------------------------------



PART I. FINANCIAL INFORMATION
Item 1. Consolidated Financial Statements


PATIENT INFOSYSTEMS INC.
CONSOLIDATED BALANCE SHEET (UNAUDITED)

ASSETS                                                                            September 30, 2003  December 31, 2002
                                                                                  ------------------  -----------------
CURRENT ASSETS:
                                                                                                     
  Cash and cash equivalents                                                                 $ 747,405           $ 5,011
  Accounts receivable                                                                         156,776           441,216
  Notes receivable                                                                          3,100,000           200,000
  Prepaid expenses and other current assets                                                   186,499           105,827
                                                                                  --------------------------------------
        Total current assets                                                                4,190,680           752,054

Property and equipment, net                                                                   184,618           285,747

Intangible assets (net of accumulated amortization of $550,937 and $443,258)                   71,786           179,465
                                                                                  --------------------------------------
TOTAL ASSETS                                                                              $ 4,447,084       $ 1,217,266
                                                                                  ======================================
LIABILITIES AND STOCKHOLDERS' DEFICIT

CURRENT LIABILITIES:
  Accounts payable                                                                          $ 644,091         $ 379,004
  Accrued salaries and wages                                                                  389,489           208,752
  Borrowings from directors                                                                 6,330,648         5,077,500
  Borrowings from shareholders                                                              1,815,447                 -
  Line of credit                                                                            3,000,000                 -
  Accrued expenses                                                                            454,665           351,621
  Accrued interest                                                                          1,169,762           713,554
  Deferred revenue                                                                            146,760           157,074
                                                                                  --------------------------------------
        Total current liabilities                                                          13,950,862         6,887,505
                                                                                  --------------------------------------

LINE OF CREDIT                                                                                      -         3,000,000

STOCKHOLDERS' DEFICIT:
  Preferred stock - $.01 par value:  shares authorized: 5,000,000
    Series C, 9% cumulative, convertible, issued and outstanding - 100,000                      1,000             1,000
    Series D, 9% cumulative, convertible, issued and outstanding - 286,182
       as of September 30, 2003                                                                 2,862                 -
  Common stock - $.01 par value:  shares authorized:
     20,000,000; issued and outstanding - 10,956,024 as of December 31, 2002 and
        10,956,454 as of September 30, 2003                                                   109,564           109,560
  Additional paid-in capital                                                               28,022,144        24,132,153
  Accumulated deficit                                                                    (37,639,348)      (32,912,952)
                                                                                  --------------------------------------
        Total stockholders' deficit                                                       (9,503,778)       (8,670,239)
                                                                                  --------------------------------------
TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT                                               $ 4,447,084       $ 1,217,266
                                                                                  ======================================

See notes to unaudited consolidated financial statements.








PATIENT INFOSYSTEMS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)
-----------------------------------------------------------------------------------------------------------------------

                                                            Three Months Ended               Nine Months Ended
                                                              September 30,                    September 30,
                                                           2003            2002             2003            2002
                                                           ----            ----             ----            ----

REVENUES
                                                                                          
  Operations Fees                                        $ 499,506       $ 521,220      $ 1,725,611     $ 1,477,176
  Consulting Fees                                          928,306          63,000        2,226,157         122,538
  Licensing Fees                                              1880            1880            5,640          28,430
                                                     ---------------------------------------------------------------
       Total revenues                                    1,429,692         586,100        3,957,408       1,628,144
                                                     ---------------------------------------------------------------
COSTS AND EXPENSES
  Cost of sales                                          1,107,776         467,162        3,054,233       1,416,741
  Sales and marketing                                      230,606         192,533          675,667         546,096
  General and administrative                               341,526         238,184          913,836         894,819
  Research and development                                  35,060          26,242          100,288          73,878
                                                     ---------------------------------------------------------------
        Total costs and expenses                         1,714,968         924,121        4,744,024       2,931,534
                                                     ---------------------------------------------------------------
OPERATING LOSS                                           (285,276)       (338,021)        (786,616)     (1,303,390)

OTHER EXPENSE
  Amortization of debt discount                          (754,101)               -      (1,467,947)              -
  Interest expense, net                                  (151,262)       (136,126)        (447,479)       (388,797)
                                                     ---------------------------------------------------------------
NET LOSS                                               (1,190,639)       (474,147)      (2,702,042)     (1,692,187)
                                                     ---------------------------------------------------------------
CONVERTIBLE PREFERRED STOCK DIVIDENDS                    (667,924)        (22,500)      (2,180,241)        (67,500)
                                                     ---------------------------------------------------------------
NET LOSS ATTRIBUTABLE TO
  COMMON STOCKHOLDERS                                $ (1,858,563)     $ (496,647)    $ (4,882,283)   $ (1,759,687)
                                                     ===============================================================
NET LOSS PER SHARE - BASIC
   AND DILUTED                                            $ (0.17)        $ (0.05)         $ (0.45)        $ (0.16)
                                                     ===============================================================
WEIGHTED AVERAGE COMMON SHARES                          10,956,424      10,956,024       10,956,185      10,956,024
                                                     ===============================================================


See notes to unaudited consolidated financial statements.







PATIENT INFOSYSTEMS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
---------------------------------------------------------------------------------------------------------------------
                                                                                 Nine Months           Nine Months
                                                                                    Ended                 Ended
                                                                             September 30, 2003    September 30, 2002
OPERATING ACTIVITIES:
                                                                                               
  Net loss                                                                     $ (2,702,042)         $ (1,692,187)
  Adjustments to reconcile net loss to net cash provided by (used in)
    operating activities:
      Depreciation and amortization                                                  236,552               292,642
      Amortization of debt discount                                                1,467,947                     -
      Gain on sale of property                                                             -                 (400)
      Decrease (increase) in accounts receivable, net                                284,440              (11,233)
      Increase in prepaid insurance, expenses and other current assets              (80,672)               (6,932)
      Increase in accounts payable                                                   265,087                 5,349
      Increase in accrued salaries and wages                                         180,737                61,088
      Increase in accrued expenses                                                   403,365               261,201
      Decrease in deferred revenue                                                  (10,314)              (21,576)
                                                                           ----------------------------------------
            Net cash provided by (used in) operating activities                       45,100           (1,112,048)
                                                                           ----------------------------------------
INVESTING ACTIVITIES:
  Property and equipment additions                                                  (27,744)               (7,060)
  Proceeds form the sale of property                                                       -                   400
  Notes receivable                                                               (2,900,000)                     -
                                                                           ----------------------------------------
          Net cash used in investing activities                                  (2,927,744)               (6,660)
                                                                           ----------------------------------------
FINANCING ACTIVITIES:
  Borrowing from directors, net                                                    1,500,000               660,000
  Borrowing from stockholders                                                      2,125,002                     -
  Line of credit borrowings                                                                -               500,000
  Exercise of incentive stock options                                                     36                     -
                                                                           ----------------------------------------
            Net cash provided by financing activities                              3,625,038             1,160,000
                                                                           ----------------------------------------
NET INCREASE IN CASH AND CASH  EQUIVALENTS                                           742,394                41,292

CASH AND CASH EQUIVALENTS AT  BEGINNING OF PERIOD                                      5,011                29,449
                                                                           ----------------------------------------
CASH AND CASH EQUIVALENTS AT  END OF PERIOD                                       $ 747,405              $ 70,741
                                                                           ========================================
Supplemental disclosures of non-cash information
  Dividend declared on convertible preferred stock                                $ 155,887              $ 67,500
                                                                           ========================================
  Beneficial conversion feature of convertible preferred stock                   $ 2,024,354
                                                                           =================
  Debt discount associated with borrowing                                        $ 2,024,354
                                                                           =================


See notes to unaudited consolidated financial statements.






PATIENT INFOSYSTEMS, INC.


Notes to  Unaudited  Consolidated  Financial  Statements  for the  period  ended
September 30, 2003

1.   The  accompanying  consolidated  financial  statements  for the three month
     periods  ended  September 30, 2003 and September 30, 2002 are unaudited and
     reflect all adjustments  (consisting only of normal recurring  adjustments)
     which are, in the opinion of management,  necessary for a fair presentation
     of the financial  position and operating  results for the interim  periods.
     These  unaudited  consolidated  financial  statements  should  be  read  in
     conjunction with the audited  consolidated  financial  statements and notes
     thereto,  together with  management's  discussion and analysis of financial
     condition  and results of  operations  contained  in the  Company's  Annual
     Report on Form 10-K for the year ended  December  31,  2002.  Certain  2002
     amounts  have been  reclassified  to  conform  to 2003  presentations.  The
     results of operations for the nine months ended  September 30, 2003 are not
     necessarily  indicative of the results for the entire year ending  December
     31, 2003.

2.   On March 28, 2003, the Company  entered into an Amended and Restated Credit
     Agreement with Wells Fargo Bank Iowa,  N.A., which extended the term of the
     $3,000,000 credit facility to January 2, 2004, under substantially the same
     terms. Certain directors of the Company guaranteed this extension.

3.   The Company  borrowed  $1,500,000  for working  capital from Mr.  Pappajohn
     during the nine month period ended  September  30, 2003. On April 10, 2003,
     the Company  replaced notes in the aggregate  principal  amount of $500,000
     owed to Mr. Pappajohn with a new note for the principal amount of $900,000,
     representing  the amount due under the  original  notes plus an  additional
     $400,000  borrowed from Mr. Pappajohn for working  capital.  As of November
     13, 2003, a total of $6,577,500  has been  borrowed from Mr.  Pappajohn and
     Dr.  Schaffer  (both  of  whom  are  members  of  the  Company's  Board  of
     Directors),  inclusive of $246,852 of  unamortized  debt  discount,  all of
     which is secured by the assets of the Company.

     On March 28, 2003, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
     Company in which they made a commitment to obtain the operating  funds that
     the Company  believes  would be sufficient to fund its  operations  through
     December 31, 2003.  There can be no assurances  given that Mr. Pappajohn or
     Dr. Schaffer can raise either the required working capital through the sale
     of the Company's  securities or that the Company can borrow the  additional
     amounts needed.

4.   On  September  23,  2002,  the  Company  signed  an  agreement  to  acquire
     substantially  all the assets of American Care Source (ACS),  headquartered
     in Dallas, Texas. This Asset Purchase Agreement was amended and restated on
     April 10,  2003 and  further  amended on July 30,  2003 and October 8, 2003
     (hereinafter,  the  amended  and  restated  Asset  Purchase  Agreement,  as
     amended,  is  referred  to as the "Asset  Purchase  Agreement").  ACS is an
     ancillary  healthcare  benefits  management  company.  It provides a bridge
     connecting  healthcare  payers and the  providers of  ancillary  healthcare
     services.  Ancillary  healthcare services include a broad array of services
     that  supplement or support the care provided by hospitals and  physicians,
     including the  non-physician  services  associated with outpatient  surgery
     centers,  free-standing diagnostic imaging centers, home infusion,  durable
     medical  equipment,  orthotics and  prosthetics,  laboratory and many other
     services.  These  ancillary  services  are provided to patients as benefits
     under group health plans and workers'  compensation  plans. ACS manages the
     administration of these ancillary healthcare benefits.


5.   On April 10,  2003,  the  Company  entered  into a Note and Stock  Purchase
     Agreement,  which the Company  amended on September 11, 2003 (the "Note and
     Stock  Purchase  Agreement")  with  certain  investors  (the  "Investors"),
     including Mr. Pappajohn, a member of the Board of Directors of the Company,
     pursuant to which the Investors  agreed to loan to the Company an aggregate
     of up to $3.5  million,  $500,000 of which  replaces  notes  payable to Mr.
     Pappajohn,  which were outstanding at March 31, 2003. In consideration  for
     the loans,  the Company  signed a series of  promissory  notes and issued a
     total of 286,182 shares of Series D 9% Cumulative  Preferred Stock ("Series
     D Preferred  Stock") to the Investors.  The notes that were  outstanding at
     June 30, 2003  totaling $2,5 million (the  "Original  Notes") were replaced
     with new notes of equal value. Except for the maturity date of November 30,
     2003,  the  replacement  notes  have  substantially  the same  terms as the
     Original  Notes.  During the quarter ended  September 30, 2003, the Company
     borrowed $1 million under the Note and Stock Purchase Agreement,  resulting
     in a total  borrowings  of $3.5 million at September  30, 2003 and the Note
     and Stock Purchase  Agreement.  All the notes bear interest at a rate equal
     to the prime rate plus 3% per annum and mature on November  30,  2003.  The
     286,182  shares of Series D  Preferred  Stock  are  convertible  into up to
     34,341,840  shares of common  stock valued at  $4,807,858.  The total value
     received by the lenders for borrowings was  $8,307,858.  In accordance with
     APB Opinion No. 14, a portion of the cash  received  totaling  $596,662 and
     $2,024,354  for the three and nine month periods ended  September 30, 2003,
     respectively,  is allocable to equity resulting in a debt discount in those
     same amounts,  which is amortized over the life of the loan. Holders of the
     Series D  Preferred  Stock  have the  right to  elect  two  members  of the
     Company's  Board of  Directors.  Upon  closing of a private  placement of a
     minimum of $4 million in value of  additional  shares of Series D Preferred
     Stock  and  after  the  closing  of the  proposed  acquisition  of ACS,  as
     contemplated by the Asset Purchase Agreement,  any notes issued pursuant to
     the Note  and  Stock  Purchase  Agreement  are  convertible  into  Series D
     Preferred  Stock.  The purpose of the loan from the Investors is to provide
     funds to the  Company  for it to loan to ACS in order  to  provide  working
     capital for the operations of ACS.

     Simultaneously  with the closing of the Note and Stock Purchase  Agreement,
     the Company and ACS entered into a Credit Agreement subsequently amended on
     July 30, 2003 (the "Credit Agreement") pursuant to which the Company agreed
     to loan to ACS up to an  aggregate  of $3.4  million  secured by all of the
     assets of ACS. As of September 30, 2003,  the Company had notes  receivable
     of $3.1 million from ACS. Patient Infosystems received warrants to purchase
     26,344  shares  of  common  stock  of ACS,  exercisable  only if the  Asset
     Purchase Agreement with ACS is terminated.  Additional warrants to purchase
     ACS common  stock may be issued  depending  on the total amount of funds it
     borrows from the Company under the Credit Agreement.

6.   The  calculations  for the basic and diluted loss per share were based upon
     loss attributable to common stockholders of $1,858,563 and $4,882,283 and a
     weighted  average  number of common shares  outstanding  of 10,956,424  and
     10,956,185  for the three and nine month periods ended  September 30, 2003,
     respectively.  The  calculations  for the basic and diluted  loss per share
     were based upon loss  attributable  to common  stockholders of $496,647 and
     $1,759,687 and a weighted  average  number of common shares  outstanding of
     10,956,024  for both the three and nine month periods  ended  September 30,
     2002,  respectively.  Options totaling  1,114,040 and 1,115,140 to purchase
     shares of common stock were outstanding but not included in the computation
     of  diluted  loss per  share for the three  and nine  month  periods  ended
     September  30, 2003 and 2002,  respectively,  because the effect would have
     been antidilutive due to the net loss in those periods.

7.   The  accompanying  unaudited  consolidated  financial  statements have been
     prepared on a going concern basis,  which  contemplates  the realization of
     assets  and  the  satisfaction  of  liabilities  in the  normal  course  of
     business.  As shown in the accompanying  unaudited  consolidated  financial
     statements, the Company incurred a net loss for the nine month period ended
     September  30,  2003 of  $4,882,283  and had  negative  working  capital of
     $9,760,182 and a stockholders' deficit of $9,503,778 at September 30, 2003.
     These factors,  among others,  may indicate that the Company will be unable
     to continue as a going concern.

     The  unaudited   consolidated  financial  statements  do  not  include  any
     adjustments  relating to the recoverability of assets and classification of
     liabilities  that  might be  necessary  should  the  Company  be  unable to
     continue as a going concern.  The Company's  ability to continue as a going
     concern is dependant upon its ability to generate  sufficient  cash flow to
     meet its  obligations.  Management  is currently  assessing  the  Company's
     operating   structure  for  the  purpose  of  reducing  ongoing   expenses,
     increasing  sources of revenue and is  negotiating  the terms of additional
     debt or equity financing.


8.   Stock-Based  Compensation  - In 2002,  the  Company  adopted  Statement  of
     Financial   Accounting   Standards   ("SFAS")  No.  148,   "Accounting  for
     Stock-Based  Compensation  -  Transition  and  Disclosure."  This  standard
     provides alternative methods of transition for voluntary change to the fair
     value based method of accounting  for  stock-based  employee  compensation.
     Additionally,  the standard  also  requires  prominent  disclosures  in the
     Company's  financial  statements  about the method of  accounting  used for
     stock-based employee  compensation,  and the effect of the method used when
     reporting financial statements.

     The Company  accounts for stock-based  compensation in accordance with SFAS
     No. 123,  "Accounting for Stock-Based  Compensation".  As permitted by SFAS
     No. 123, the Company continues to measure compensation for such plans using
     the intrinsic  value based method of  accounting,  prescribed by Accounting
     Principles Board ("APB"),  Opinion No. 25,  "Accounting for Stock Issued to
     Employees."   Had   compensation   cost  for  the   Company's   stock-based
     compensation  plans been determined  based on the fair value at the date of
     grant for  awards  consistent  with the  provisions  of SFAS No.  123,  the
     Company's net loss and net loss per share would have been  increased to the
     pro forma amounts indicated below:




                                               Three Months Ended             Nine Months Ended
                                                  September 30,                 September 30,
                                               2003           2002           2003           2002
                                               ----           ----           ----           ----
     Net loss attributable to common
                                                                            
     shareholders - as reported           ($1,858,563)     ($496,647)   ($4,882,283)    ($1,759,687)

     Stock compensation expense               (30,961)       (31,693)       (88,123)        (99,495)
                                          -----------------------------------------------------------
     Net loss - pro forma                 ($1,889,524)     ($528,340)   ($4,970,406)    ($1,859,182)

     Net loss per share - basic
       and diluted - as reported               ($0.17)        ($0.05)        ($0.45)         ($0.16)

     Net loss per share - basic
       and diluted - pro forma                 ($0.17)        ($0.05)        ($0.45)         ($0.17)



     The fair value of each option grant is estimated on the date of grant using
     the Black-Scholes  option-pricing model using an assumed risk-free interest
     rates of 3.75% as of  September  30, 2003 and an expected  life of 7 years.
     The assumed  dividend  yield was zero.  The  Company has used a  volatility
     factor of 1.56 for the year ended  September 30, 2003.  For purposes of pro
     forma  disclosure,  the estimated fair value of each option is amortized to
     expense over that option's vesting period and only the compensation expense
     related to the three and nine month  periods  ended  September 30, 2002 and
     2003 were used to adjust the net loss on a pro forma basis.

9.   Changes in  additional  paid in capital  for the nine  month  period  ended
     September  30,  2003 were as  follows:

     Balance as of  December 31, 2002                   $ 24,132,153

         Series C dividends                                 (67,500)
         Series D dividends                                 (88,387)
         Value of 286,182 shares of Series D issued
             Portion of debt allocated to stock            2,021,492
             Beneficial conversion feature                 2,024,354
         Value of 400 shares common stock issued                  32
                                                       -------------
                                                        $ 28,022,144
                                                       =============



Item 2. Management's  Discussion and Analysis of Financial Condition and Results
     of Operations.

     Management's  discussion  and analysis  provides a review of the  Company's
operating  results for the three and nine month periods ended September 30, 2003
as compared to the three and nine month periods  ended  September 30, 2002 and a
review of the Company's financial condition at September 30, 2003 as compared to
September  30, 2002 and December  31,  2002.  The focus of this review is on the
underlying  business  reasons for significant  changes and trends  affecting the
revenues,  net earnings  and  financial  condition  of the Company.  This review
should  be read in  conjunction  with the  accompanying  unaudited  consolidated
financial statements.

     In an effort to give investors a well-rounded view of the Company's current
condition  and  future  opportunities,  this  Quarterly  Report  on Form  10-QSB
includes  forecasts by the Company's  management  about future  performance  and
results.   Because   they   are   forward-looking,   these   forecasts   involve
uncertainties. These uncertainties include the Company's ability to continue its
operations  as a result of,  among  other  things,  continuing  losses,  working
capital short falls,  uncertainties with respect to sources of capital, risks of
market  acceptance  of or  preference  for the  Company's  systems and services,
competitive  forces,  the impact of changes in government  regulations,  general
economic factors in the healthcare  industry and other factors  discussed in the
Company's  filings with the  Securities  and Exchange  Commission  including the
Company's Annual Report on Form 10-K for the year ended December 31, 2002.

     On May 29, 2002, the Company entered into a Strategic Marketing Partnership
Agreement with USI Administrators, Inc. ("CBCA"). The Company and CBCA each gave
the other the  non-exclusive  right to sell certain  products and services.  The
supplier  of the  product or service  is paid in  accordance  with an agreed fee
schedule. The difference between the selling price and the fee schedule, if any,
is the seller's fee entitlement. Either party may terminate the agreement at any
time with 180 days notification.

     On  September  23,  2002,  the  Company  signed  an  agreement  to  acquire
substantially  all the assets of American  Care Source (ACS),  headquartered  in
Dallas,  Texas. This Asset Purchase  Agreement was amended and restated on April
10,  2003  and  subsequently  amended  on July  30,  2003 and  October  8,  2003
(hereinafter,  the amended and restated Asset Purchase Agreement as amended,  is
referred to as the "Asset Purchase  Agreement").  ACS is an ancillary healthcare
benefits management  company. It provides a bridge connecting  healthcare payers
and  the  providers  of  ancillary  healthcare  services.  Ancillary  healthcare
services  include a broad array of services that  supplement or support the care
provided by hospitals  and  physicians,  including  the  non-physician  services
associated with outpatient  surgery centers,  free-standing  diagnostic  imaging
centers,  home infusion,  durable medical equipment,  orthotics and prosthetics,
laboratory and many other  services.  These  ancillary  services are provided to
patients as benefits under group health plans and workers'  compensation  plans.
ACS manages the administration of these ancillary healthcare benefits.

     Under the terms of the Asset Purchase  Agreement,  the Company will acquire
the assets of ACS in exchange for shares of common stock of the Company equal to
approximately  sixteen  percent  (16%) of the fully diluted  outstanding  common
stock of the Company,  without giving effect to a private placement  anticipated
to be  completed  prior to the  closing of the  acquisition  in order to provide
working  capital.  The ACS  beneficial  ownership  of the  Company  will  change
depending of the terms and amount of equity sold in any private  placement.  The
agreement  contains  various  conditions  to  closing,  some of which may not be
satisfied.  Therefore  completion  of the  transaction  cannot be assured  until
closing. Among the conditions to closing are the following:

o    the approval of the  stockholders  of the Company of certain  amendments to
     its Certificate of Incorporation;

o    the  execution  by  certain  shareholders  of  ACS  and  the  Company  of a
     Shareholders'  Agreement  providing for the voting of shares of the Company
     in favor of the election of certain  individuals  to the board of directors
     of the Company;


o    the execution of agreements by John  Pappajohn and Derace  Schaffer to hold
     all indebtedness of the Company in abeyance until September 30, 2004;

o    written documentation that the bank debt of the Company to Wells Fargo Bank
     has been renegotiated so as to provide a grace and forbearance period until
     December 31, 2003, before any principal payments are required and that John
     Pappajohn and Derace  Schaffer will remain  guarantors of such bank debt if
     required by Wells Fargo Bank;

o    the  execution  of a Voting  Agreement by each  stockholder  of the Company
     owning  more than 10% of the  outstanding  shares  of  common  stock of the
     Company; and

o    fulfillment  of  customary  contractual  conditions  set forth in the Asset
     Purchase Agreement.

     The  Asset  Purchase  Agreement  may  be  terminated  and  the  acquisition
abandoned  at any time prior to the closing  date of the  transaction  under the
following conditions:

o    by mutual agreement in writing by the Company and ACS;

o    by either the Company or ACS if the other party materially  breaches any of
     the representations,  warranties,  covenants or agreements set forth in the
     Asset  Purchase  Agreement  at the time of its  execution or on the closing
     date; or

o    by either the Company or ACS if the other party fails to perform timely, in
     all material  aspects the covenants and obligations  that it is required to
     perform  under Asset  Purchase  Agreement and such party does not obtain in
     writing a waiver of such performances;

     The Company has filed a preliminary proxy statement with the Securities and
Exchange Commission with respect to a meeting of stockholders to obtain approval
of, among other  things,  certain  amendments to the  Company's  certificate  of
incorporation necessary to consummate the proposed transaction with ACS.


Results of Operations

     Revenues

     Revenues  consist  of  revenues  from  operations,   development  fees  and
licensing fees.  Revenues increased to $1,429,692 from $586,100 during the three
months  ended  September  30,  2003 and 2002,  respectively,  or 144%.  Revenues
increased to $3,957,408 from  $1,628,144  during the nine months ended September
30, 2003 and 2002, respectively, or 143%.



                                         Three Months Ended                Nine Months Ended
                                           September 30,                     September 30,
Revenues                               2003              2002            2003              2002
--------                               ----              ----            ----              ----
Operations Fees
                                                                          
  Consulting                        $ 928,306         $ 63,000      $ 2,226,157         $ 122,538
  Disease and demand management       467,726          472,892        1,600,730         1,302,505
  Surveys                              24,701           42,428           84,077           147,233
Development Fees                        7,079            5,900           40,804            27,438
Licensing Fees                          1,880            1,880            5,640            28,430
                                 ------------------------------   --------------------------------
Total Revenues                    $ 1,429,692        $ 586,100      $ 3,957,408       $ 1,628,144
                                 ------------------------------   --------------------------------



     The Company's  consulting revenue was primarily  attributable to assistance
provided to  organizations  for the  development of clinical  registries used to
increase effective  management of patients with chronic disease.  The Company is
supporting the development,  including project management and implementation, of
a patient registry for federally  qualified  health centers,  through a national
initiative  known  as  the  Health  Disparities   Collaboratives.   The  Company
participates in this project as a subcontractor  of the Institute for Healthcare
Improvement.  While the  Company  anticipates  that it will  continue to provide
these and other consulting services, no assurances can be given that the Company
will continue to provide these  services at the current  levels,  or at all, and
revenue  recognized  during the three and nine month periods ended September 30,
2003 is not  necessarily  indicative  of the  results for the entire year ending
December 31, 2003.

     The  changes in the  Company's  disease and demand  management  revenue was
primarily  attributable to new customers and a joint marketing relationship that
has  contributed  new  sources  of  revenue  net  of  revenue  lost  due  to the
termination of two customers.  The new customers accounted for increased revenue
of $125,307 and $386,153 for the three and nine month  periods  ended  September
30, 2003. Revenues from the joint marketing  relationship increased from $24,955
and $67,055  for the three and nine month  periods  ended  September  30,  2002,
respectively,  to $226,999 and $571,688 for the same respective periods of 2003.
The Company  received revenue of $1,200 and $317,753 as compared to $330,157 and
$859,730 for the three and nine month periods ended September 30, 2003 and 2002,
respectively,  from terminated  service  agreements.  The Company has identified
other possible new customers,  but there can be no assurance that such prospects
will contribute revenue in the near term, or at all.

     Development fee revenues were $7,079 and $5,900 for the three month periods
ended September 30, 2003 and 2002,  respectively and $40,804 and $27,438 for the
nine month periods ended September 30, 2003 and 2002, respectively.  The Company
received  development  revenues from a variety of customers for  modification of
specific  programs.  The Company has completed  substantially all services under
these agreements and anticipates primarily receiving development fee revenues in
connection  with the  enhancement  of its  existing  programs.  Development  fee
revenues include clinical,  technical and operational design and modification of
the Company's  programs.  The Company  anticipates that revenue from development
fees will  continue  to be low unless the Company  enters  into new  development
agreements.


     License fee revenues  recognized  from the Case  Management  Support System
were $1,880 for the three month  periods  ended  September 30, 2003 and 2002 and
$5,640 and $28,430 for the nine month periods ended September 30, 2003 and 2002,
respectively.  The Company has not entered into any new licensing agreements for
its Case  Management  Support  System and the  revenue  for the  current  period
reflects revenue generated exclusively from the existing agreement.

     Costs and Expenses

     Cost of sales includes salaries and related benefits,  services provided by
third  parties,  and  other  expenses  associated  with the  implementation  and
delivery  of  the  Company's  consulting   services,   standard  and  customized
population,  demand and disease management programs. Cost of sales for the three
and nine month periods ended  September 30, 2003 was $1,107,776 and  $3,054,233,
respectively,  as  compared to $467,162  and  $1,416,741  for the three and nine
month  periods  ended  September  30,  2002.  The  increase  in these  costs was
primarily the result of increased  operational  activity.  The  Company's  gross
margin,  being the  percentage  of revenues  available to offset other costs and
expenses  after  subtracting  the cost of sales  was 23% for the  three and nine
month periods  ended  September 30, 2003 as compared to 20% and 13% for the same
respective  periods of 2002. The Company  anticipates that revenue must increase
for it to  recognize  economies  of scale  adequate to improve its  margins.  No
assurance  can be given that  revenues  will  increase or that, if they do, they
will continue to exceed costs and expenses.

     Sales  and  marketing  expenses  consist  primarily  of  salaries,  related
benefits,  travel costs,  sales materials and other marketing  related expenses.
Sales  and  marketing  expenses  for the  three  and nine  month  periods  ended
September  30, 2003 were  $230,606 and  $675,667,  respectively,  as compared to
$192,533 and $546,096 for the same respective periods of 2002.  Spending in this
area has increased due to an increase in sales activity. The Company anticipates
expansion  of the  Company's  sales  and  marketing  staff and  expects  it will
continue to invest in the sales and  marketing  process,  and that such expenses
related to sales and marketing might increase in future periods.

     General  and  administrative   expenses  include  the  costs  of  corporate
operations,  finance and accounting, human resources and other general operating
expenses of the Company.  General and administrative  expenses for the three and
nine month  periods ended  September  30, 2003 were  $341,526 and  $913,836,  as
compared to $238,184 and $894,819 for the same respective periods of 2002. These
expenditures  have  been  incurred  to  maintain  the  corporate  infrastructure
necessary  to support  anticipated  program  operations.  The  increase in these
expenses is due primarily to reversing a $114,953 accrued expense as a result of
a renegotiated vendor contract during August of 2002.

     Research and development expenses consist primarily of salaries and related
benefits and  administrative  costs  associated  with the development of certain
components of the Company's integrated  information capture and delivery system,
as well as development of the Company's standardized disease management programs
and the Company's Internet based technology  products.  Research and development
expenses  for the three and nine month  periods  ended  September  30, 2003 were
$35,060 and $100,288,  respectively,  as compared to $26,242 and $73,878 for the
same respective periods of 2002.

     Amortization of debt discount was $754,101 and $1,467,947 for the three and
nine month periods ended September 30, 2003, respectively.  This cost relates to
the issuance of equity to, and incurrence of debt from, certain lenders pursuant
to the Note and Stock Purchase  Agreement dated April 10, 2003 and as amended on
September  11,  2003,  pursuant to which the  lenders  agreed to make short term
loans to the Company.  The total value  received by the lenders from the Company
under the Note and Stock  Purchase  Agreement  as  amended  was  $8,307,858.  In
accordance  with APB  Opinion  No. 14, a portion of the cash  received  totaling
$1,427,692  and 596,662 for the quarters  ended June 30 and  September 30, 2003,
respectively,  is allocable to equity resulting in a debt discount in those same
amounts, which is amortized over the life of the loan. As of September 30, 2003,
the Company had amortized  $1,467,947 of the total debt discount of  $2,024,354.
The  remaining  $556,407  will be  amortized  over the two month  period  ending
November  30,  2003.  If  additional  amounts  must be  borrowed,  there  may be
additional   consideration  to  the  lenders  and  additional   financing  costs
associated with such loans, which may increase financing costs and may cause the
life the life of this intangible asset to be adjusted.


     The Company  recorded net interest expense of $151,262 and $447,479 for the
three and nine month periods ended September 30, 2003, respectively, as compared
to $136,126 and $388,797 for the same  respective  periods of 2002,  principally
due to the net increase of interest expense on debt.

     Income (loss)

     The Company had a net loss  attributable to the common  stockholders  after
preferred stock  dividends,  of $1,858,563 and $4,882,283 for the three and nine
month periods ended September 30, 2003, respectively,  with a net loss per share
of $0.17  and  $0.45 per share  for the same  respective  periods.  Without  the
financing cost of $754,101 and $1,467,947 and the beneficial  conversion feature
of $596,662 and $2,024,354 for the three and nine month periods ended  September
30, 2003,  respectively,  the Company had a net loss  attributable to the common
shareholders after preferred stock dividends, of $507,800 and $1,389,982 for the
three and nine month periods ended September 30, 2003, respectively, as compared
to $496,647 and $1,759,687 for the three and nine month periods ended  September
30, 2002. This represents a net loss per common share of $0.05 and $0.13 for the
three and nine month periods ended September 30, 2003,  compared to the net loss
of $0.05 and $0.16 per common  share  shown for the same  respective  periods of
2002.

     Liquidity and Capital Resources

     At  September  30,  2003,  the  Company  had a working  capital  deficit of
$9,760,182 as compared to $6,135,451 at December 31, 2002. Through September 30,
2003,  these amounts reflect the effects of the Company's  continuing  losses as
well as increased borrowings,  $3,000,000 of which was classified as a long-term
liability  at December  31, 2002 but is  classified  as a current  liability  at
September 30, 2003.  Since its inception,  the Company has primarily  funded its
operations,  working  capital  needs and capital  expenditures  from the sale of
equity securities or the incurrence of debt.

     On March 28, 2003, the Company  entered into an Amended and Restated Credit
Agreement  with Wells  Fargo Bank Iowa,  N.A.,  which  extended  the term of the
Company's $3,000,000 credit facility to January 2, 2004, under substantially the
same terms. Certain directors of the Company guaranteed this extension.

     The Company  borrowed  $1,500,000  for working  capital from Mr.  Pappajohn
during the nine month period ended  September 30, 2003.  On April 10, 2003,  the
Company replaced notes in the aggregate principal amount of $500,000 owed to Mr.
Pappajohn with a new note for the principal amount of $900,000, representing the
amount due under the original  notes plus an additional  $400,000  borrowed from
Mr.  Pappajohn  for  working  capital.  As of  November  13,  2003,  a total  of
$6,577,500 has been borrowed from Mr.  Pappajohn and Dr.  Schaffer (both of whom
are  members of the  Company's  Board of  Directors),  inclusive  of $246,852 of
unamortized debt discount, all of which is secured by the assets of the Company.

     On March 28, 2003, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
Company in which they made a commitment to obtain the  operating  funds that the
Company believes would be sufficient to fund its operations through December 31,
2003.  There can be no assurances  given that Mr.  Pappajohn or Dr. Schaffer can
raise  either the required  working  capital  through the sale of the  Company's
securities or that the Company can borrow the additional amounts needed.

     On April 10,  2003,  the  Company  entered  into a Note and Stock  Purchase
Agreement,  which the Company amended on September 11, 2003 (the "Note and Stock
Purchase  Agreement") with certain  investors (the  "Investors"),  including Mr.
Pappajohn, a member of the Board of Directors of the Company,  pursuant to which
the Investors  agreed to loan to the Company an aggregate of up to $3.5 million,
$500,000  of  which  replaces  notes  payable  to  Mr.  Pappajohn,   which  were
outstanding  at March 31,  2003.  In  consideration  for the loans,  the Company
signed a series of  promissory  notes and  issued a total of  286,182  shares of
Series D 9%  Cumulative  Preferred  Stock  ("Series D  Preferred  Stock") to the
Investors.  The notes  that were  outstanding  at June 30,  2003  totaling  $2.5
million  (the  "Original  Notes") were  replaced  with new notes of equal value.
Except for the maturity date of November 30, 2003,  the  replacement  notes have
substantially  the same terms as the Original  Notes.  During the quarter  ended
September  30, 2003,  the Company  borrowed $1 million  under the Note and Stock
Purchase  Agreement,  resulting in total borrowings of $3.5 million at September
30, 2003 and the Note and Stock Purchase Agreement.  All the notes bear interest
at a rate equal to the prime rate plus 3% per annum and mature on  November  30,
2003.  The  286,182  shares of Series D  Preferred  Stock are  convertible  into
34,341,840  shares of common stock of the  Company,  valued at  $4,807,858.  The
total value received by the lenders for borrowings was $8,307,858. In accordance
with APB Opinion No. 14, a portion of the cash  received  totaling  $596,662 and
$2,024,354  for the three and nine  month  periods  ended  September  30,  2003,
respectively,  is allocable to equity resulting in a debt discount in those same
amounts,  which is amortized over the life of the loan.  Holders of the Series D
Preferred  Stock have the right to elect two members of the  Company's  Board of
Directors.  Upon  closing of a private  placement  of a minimum of $4 million in
value of additional  shares of Series D Preferred Stock and after the closing of
the  proposed  acquisition  of  ACS,  as  contemplated  by  the  Asset  Purchase
Agreement,  any notes issued  pursuant to the Note and Stock Purchase  Agreement
are convertible  into Series D Preferred Stock. The purpose of the loan from the
Investors  is to provide  funds to the Company for it to loan to ACS in order to
provide working capital for the operations of ACS.

     Simultaneously  with the closing of the Note and Stock Purchase  Agreement,
the Company and ACS entered into a Credit Agreement subsequently amended on July
30, 2003 (the "Credit  Agreement")  pursuant to which the Company agreed to loan
to ACS up to an aggregate  of $3.4 million  secured by all of the assets of ACS.
As of September 30, 2003, the Company had notes  receivable of $3.1 million from
ACS. Patient  Infosystems  received warrants to purchase 26,344 shares of common
stock of ACS,  exercisable  only if the  Asset  Purchase  Agreement  with ACS is
terminated.  Additional  warrants  to  purchase  ACS common  stock may be issued
depending  on the total  amount of funds it borrows  from the Company  under the
Credit Agreement.

     The Company has expended  substantial  funds to establish  its  operational
capabilities and  infrastructure.  The Company's cash has been steadily depleted
as a result of operating  losses.  The Company  anticipates that its losses will
continue and, but for the continuing loans from Mr.  Pappajohn,  the Company has
no  available  cash to continue  operations.  Accordingly,  the Company has been
required to seek cash to maintain its operations.  The Company is continuing its
efforts to raise  additional  funds  privately,  which may  involve  the sale of
convertible  preferred  stock or further debt  securities.  No assurance  can be
given  that the  Company  will  successfully  raise  the  necessary  funds.  Any
additional  financing,  which includes the issuance of additional  securities of
the Company,  may be dilutive to the  Company's  existing  stockholders.  If the
Company  is unable  to raise  additional  funds,  it will be  required  to cease
operations.


     Inflation

     Inflation did not have a significant  impact on the Company's  costs during
the three and nine month periods ended  September 30, 2003 and 2002. The Company
continues  to monitor the impact of  inflation  in order to minimize its effects
through pricing strategies, productivity improvements and cost reductions.


     Forward Looking Statements

     When used in this and in future  filings by the Company with the Securities
and Exchange Commission,  in the Company's press releases and in oral statements
made with the approval of an authorized  executive  officer of the Company,  the
words or phrases "will likely result,"  "expects," "plans," "will continue," "is
anticipated,"  "estimated,"  "project,"  or  "outlook"  or  similar  expressions
(including  confirmations by an authorized  executive  officer of the Company of
any such  expressions  made by a third party with  respect to the  Company)  are
intended  to  identify  "forward-looking  statements"  within the meaning of the
Private Securities  Litigation Reform Act of 1995. The Company wishes to caution
readers not to place undue reliance on any such forward-looking statements, each
of which speak only as of the date made.  Such statements are subject to certain
risks and  uncertainties  that could cause actual  results to differ  materially
from  historical  earnings and those presently  anticipated or projected.  These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital short falls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of changes in government  regulations,  general  economic  factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the Securities and Exchange Commission  including the Company's Annual Report on
Form 10-K for the year ended December 31, 2002. The Company has no obligation to
publicly  release  the  result  of  any  revisions,  which  may be  made  to any
forward-looking  statements to reflect  anticipated or  unanticipated  events or
circumstances occurring after the date of such statements.

Item 3. Controls and Procedures.

     Our management,  with the  participation of our Chief Executive Officer and
Vice  President,  Financial  Planning,  has evaluated the  effectiveness  of our
disclosure  controls and  procedure as of  September  30, 2003.  Based upon this
evaluation,  our Chief Executive Officer and Vice President,  Financial Planning
concluded  that our  disclosure  controls and  procedures  are effective for the
recording, processing,  summarizing and reporting the information the Company is
required to disclose in the reports it files under the  Securities  Exchange Act
of 1934,  within the time periods  specified in the SEC's rules and forms.  Such
evaluation  did not identify any change in our internal  control over  financial
reporting  that occurred  during the quarter  ended  September 30, 2003 that has
materially affected,  or is reasonably likely to materially affect, our internal
control over financial reporting.




PART II - OTHER INFORMATION

Item 2.  Changes in Securities and Use of Proceeds

     Borrowing from directors

     On April 10,  2003,  the  Company  entered  into a Note and Stock  Purchase
Agreement,  which the Company amended on September 11, 2003 (the "Note and Stock
Purchase  Agreement") with certain  investors (the  "Investors"),  including Mr.
Pappajohn, a member of the Board of Directors of the Company,  pursuant to which
the Investors  agreed to loan to the Company an aggregate of up to $3.5 million,
$500,000  of  which  replaces  notes  payable  to  Mr.  Pappajohn,   which  were
outstanding  at March 31,  2003.  In  consideration  for the loans,  the Company
signed a series of  promissory  notes and  issued a total of  286,182  shares of
Series D 9%  Cumulative  Preferred  Stock  ("Series D  Preferred  Stock") to the
Investors.  The notes  that were  outstanding  at June 30,  2003  totaling  $2.5
million  (the  "Original  Notes") were  replaced  with new notes of equal value.
Except for the maturity date of November 30, 2003,  the  replacement  notes have
substantially  the same terms as the Original Notes. All the notes bear interest
at a rate equal to the prime rate plus 3% per annum and mature on  November  30,
2003.  The  286,182  shares of Series D  Preferred  Stock are  convertible  into
34,341,840 shares of common stock of the Company,  valued at $4,807,858.  During
the quarter ended September 30, 2003, the Company  borrowed $1 million under the
Note and Stock Purchase Agreement, resulting in total borrowings of $3.5 million
at September 30, 2003 and the Note and Stock Purchase Agreement. The total value
received by the lenders for borrowings was  $8,307,858.  In accordance  with APB
Opinion No. 14, a portion of the cash received  totaling $596,662 and $2,024,354
for the three and nine month periods ended September 30, 2003, respectively,  is
allocable to equity resulting in a debt discount in those same amounts, which is
amortized  over the life of the loan.  Holders of the Series D  Preferred  Stock
have the right to elect two members of the Company's  Board of  Directors.  Upon
closing of a private placement of a minimum of $4 million in value of additional
shares  of Series D  Preferred  Stock and  after  the  closing  of the  proposed
acquisition of ACS, as contemplated by the Asset Purchase  Agreement,  any notes
issued pursuant to the Note and Stock Purchase  Agreement are  convertible  into
Series D  Preferred  Stock.  The  purpose of the loan from the  Investors  is to
provide  funds to the Company for it to loan to ACS in order to provide  working
capital for the operations of ACS. See "Liquidity and Capital Resources".


Item 6.  Exhibits and Reports on Form 8-K


(a)  Exhibits

     See Exhibit Index.

(b)  Reports on Form 8-K:

         None.


     SIGNATURES

In accordance with the requirements of the Securities  Exchange Act of 1934, the
registrant  caused  this  report to be signed on its behalf by the  undersigned,
thereunto duly authorized.


                                                  PATIENT INFOSYSTEMS, INC.


Date: November 13, 2003                  /s/Roger L. Chaufournier
      ------------------------------    ------------------------------
                                            Roger L. Chaufournier
                                            Director, President and
                                            Chief Executive Officer
                                            (authorized officer)

Date: November 13, 2003                  /s/Kent A. Tapper
      ------------------------------    ------------------------------
                                            Kent A. Tapper
                                            Vice President, Financial Planning
                                            (principal accounting officer)





                                  EXHIBIT INDEX


EXHIBIT
NUMBER                       DESCRIPTION

11   Statements of Computation of Per Share Earnings.

10.67Amendment  No1 to the Amended and Restated  Agreement  for the Purchase and
     Sale of Assets dated as of July 30, 2003 between  Patient  Infosystems  and
     American Caresource Corporation.

10.68Amendment  No1 to  the  Note  and  Stock  Purchase  Agreement  dated  as of
     September 11, 2003 between Patient Infosystems and a group of investors.

10.69Amendment  No1 to the Credit  Agreement  dated as of July 30, 2003  between
     Patient Infosystems and American Caresource Corporation.

10.70Amendment  No2 to the Amended and Restated  Agreement  for the Purchase and
     Sale of Assets dated as of October 8, 2003 between Patient  Infosystems and
     American Caresource Corporation.


31.1 Certification  of Roger  Chaufournier  required by Rule  13a-14(a)  or Rule
     15d-14(a)

31.2 Certification of Kent Tapper required by Rule 13a-14(a) or Rule 15d-14(a)

32.1 Certification  of Roger  Chaufournier  and  Kent  Tapper  required  by Rule
     13a-14(b) or Rule  15d-14(b) and Section 906 of the  Sarbanes-Oxley  Act of
     2002, 18 U.S.C. Section 1350






Exhibit 11. Statement of Computation of Per Share Earnings

PATIENT INFOSYSTEMS, INC.



                                                     Three Months Ended                        Nine Months Ended
                                                        September 30,                            September 30,
                                                   2003               2002                  2003               2002
                                                   ----               ----                  ----               ----
                                                                                               
Net loss                                       $ (1,190,639)       $ (474,147)          $ (2,702,042)      $ (1,692,187)

Convertible preferred Stock dividends              (667,924)          (22,500)            (2,180,241)           (67,500)
                                               -------------------------------          --------------------------------
Net loss attributable to
     Common Stockholders                       $ (1,858,563)       $ (496,647)          $ (4,882,283)      $ (1,759,687)
                                               -------------------------------          --------------------------------
Weighted average common shares                    10,956,424        10,956,024             10,956,185         10,956,024
                                               -------------------------------          --------------------------------
Net loss per share - Basic and diluted              $ (0.17)          $ (0.05)               $ (0.45)           $ (0.16)
                                               ===============================          ================================